Function of mitochondrial Stat3 in cellular respiration.

Science
Joanna WegrzynAndrew C Larner

Abstract

Cytokines such as interleukin-6 induce tyrosine and serine phosphorylation of Stat3 that results in activation of Stat3-responsive genes. We provide evidence that Stat3 is present in the mitochondria of cultured cells and primary tissues, including the liver and heart. In Stat3(-/-) cells, the activities of complexes I and II of the electron transport chain (ETC) were significantly decreased. We identified Stat3 mutants that selectively restored the protein's function as a transcription factor or its functions within the ETC. In mice that do not express Stat3 in the heart, there were also selective defects in the activities of complexes I and II of the ETC. These data indicate that Stat3 is required for optimal function of the ETC, which may allow it to orchestrate responses to cellular homeostasis.

References

Aug 24, 1999·Cell·J F BrombergJ E Darnell
Mar 4, 2003·The Journal of Biological Chemistry·James MurrayRoderick A Capaldi
Jul 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jun ZhangDhananjaya V Kalvakolanu
Oct 21, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jörg J JacobyXin-Yuan Fu
Apr 8, 2006·The Journal of Biological Chemistry·Ana M GameroAndrew C Larner
May 24, 2006·Molecular and Cellular Biochemistry·Ling ZhangStephanie S Watowich
Feb 10, 2007·Cell·Denise Hilfiker-KleinerHelmut Drexler
Oct 16, 2007·Oncogene·S J BakerE P Reddy

❮ Previous
Next ❯

Citations

Oct 13, 2010·Basic Research in Cardiology·Roisin F KellySandrine Lecour
Sep 28, 2010·Cell and Tissue Research·Lee J Quinton, Joseph P Mizgerd
Mar 7, 2012·Cardiovascular Drugs and Therapy·Sarin J SomersSandrine Lecour
Sep 23, 2010·Journal of Clinical Immunology·Attila KumánovicsHarry R Hill
Jun 4, 2013·Seminars in Cancer Biology·Federico PietrocolaGuido Kroemer
Aug 11, 2012·The Proceedings of the Nutrition Society·Caroline André, Daniela Cota
Mar 10, 2012·Cell Death and Differentiation·M DemariaV Poli
Feb 1, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Fouad A ZoueinGeorge W Booz
Sep 30, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C CataniaD Cota
Sep 6, 2011·Nature Neuroscience·Daniel Alvarez-FischerAlain Prochiantz
Sep 29, 2011·Nature Neuroscience·Laurie H Sanders, J Timothy Greenamyre
Oct 20, 2012·Nature Reviews. Immunology·Susan M Kaech, Weiguo Cui
Jul 28, 2013·Nature Reviews. Immunology·Joshua D Milner, Steven M Holland
Nov 20, 2013·Nature Reviews. Nephrology·Branko BraamCarlo A Gaillard
Oct 9, 2013·Nature Reviews. Rheumatology·Andras Perl
Apr 18, 2012·Proceedings of the National Academy of Sciences of the United States of America·Rui KangHerbert J Zeh
Aug 15, 2012·Proceedings of the National Academy of Sciences of the United States of America·Joana Pinto CoutoJacqueline F Bromberg
Dec 8, 2010·The Journal of Biological Chemistry·Amandine ChaixPaulo De Sepulveda
Apr 7, 2011·The Journal of Biological Chemistry·Michel BernierRafael de Cabo
Jun 21, 2011·The Journal of Biological Chemistry·Sheu-Fen LeeGang Yu
Dec 29, 2012·The Journal of Biological Chemistry·Prasad TammineniNaresh Babu Venkata Sepuri
Sep 26, 2012·The Journal of Biological Chemistry·Giuseppe CanninoEric Dufour
Jan 11, 2013·The Journal of Biological Chemistry·Michele TavecchioDario C Altieri
Oct 7, 2009·Antioxidants & Redox Signaling·Werner J H KoopmanPeter H G M Willems
Dec 5, 2009·Antioxidants & Redox Signaling·Nicole BüchnerJudith Haendeler
Jun 29, 2010·Antioxidants & Redox Signaling·Kerstin BoenglerRainer Schulz
Jul 10, 2010·Antioxidants & Redox Signaling·Fabio Di LisaMartina Semenzato
Aug 18, 2010·Antioxidants & Redox Signaling·Hung Wen LinMiguel A Perez-Pinzon
Dec 8, 2011·Antioxidants & Redox Signaling·Diane E Handy, Joseph Loscalzo
Sep 2, 2010·Cardiovascular Research·Marjan Gucek, Elizabeth Murphy
Feb 10, 2011·European Heart Journal·Sandrine Lecour, Richard W James
May 6, 2009·Human Reproduction Update·João Ramalho-SantosAlexandra Amaral
Dec 19, 2012·Molecular Human Reproduction·A P SobinoffE A Mclaughlin
May 2, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Samuel N HeymanChristian Rosenberger
Nov 15, 2011·Current Opinion in Oncology·John R P Knight, Jo Milner
Oct 4, 2011·Journal of Cardiovascular Pharmacology·Qun ChenEdward J Lesnefsky

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.