Function of Nanos2 in the male germ cell lineage in mice.

Cellular and Molecular Life Sciences : CMLS
Yumiko Saga

Abstract

Nanos is known as an evolutionarily conserved RNA-binding protein, the function of which is implicated in germ cell development. This includes the maintenance of both the primordial germ cells (PGCs) and germline stem cells. In mice, Nanos2 exhibits a unique feature in which its expression is induced only in the germ cells within the sexually determined male gonad. Nanos2 promotes male germ cell differentiation, while simultaneously suppressing a female program. In addition, Nanos2 is also expressed in the spermatogonial stem cells and functions as an intrinsic factor to maintain the stem cell population during spermatogenesis. Detailed cytological and biochemical analyses in embryonic male gonads in the mouse have revealed that Nanos2 localizes to the P-bodies, a center of RNA processing. It has also been shown that the Nanos2 interacts with protein components of the deadenylation complex involved in the initial step of the RNA degradation pathway.

References

Jul 1, 1997·Developmental Biology·A McLaren, D Southee
Sep 3, 1999·Mechanisms of Development·H MacArthurM L King
Nov 18, 2000·Journal of Endocrinological Investigation·P RossiR Geremia
Jan 11, 2001·Development Genes and Evolution·K MochizukiT Fujisawa
Feb 28, 2001·Reproduction : the Official Journal of the Society for the Study of Fertility·D G de Rooij
Sep 22, 2001·Cell Structure and Function·A McLaren
Aug 30, 2003·Science·Masayuki TsudaYumiko Saga
May 25, 2004·Nature Genetics·F William BuaasRobert E Braun
Jul 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Yoshiki HayashiSatoru Kobayashi
Aug 25, 2004·Science·Aleksandar RajkovicMartin M Matzuk
Nov 30, 2004·Gene Expression Patterns : GEP·Yasuhiro SakaiShoji Tajima
Feb 11, 2005·Nature·Karl-Ludwig LaugwitzKenneth R Chien
Jul 15, 2005·Biology of Reproduction·Anyanee BuageawStefan Schlatt
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jana KoubovaDavid C Page
Apr 1, 2006·Science·Josephine BowlesPeter Koopman
Jun 30, 2006·Mechanisms of Development·Masayuki TsudaYumiko Saga
Oct 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Shinichiro ChumaNorio Nakatsuji
Jan 24, 2007·Physiological Reviews·Dagmar WilhelmPeter Koopman
Jan 24, 2007·Molecular and Cellular Biology·Yong ChengPeijing Jeremy Wang
Mar 14, 2007·Molecular Cell·Roy Parker, Ujwal Sheth
Jun 23, 2007·Endocrinology·Glenn MacLeanMartin Petkovich
Dec 20, 2007·Developmental Biology·Francesca LolicatoPaola Grimaldi
Feb 19, 2008·Genes & Development·Atsushi Suzuki, Yumiko Saga
Feb 29, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nara I MuraroRichard A Baines
May 30, 2008·Biology of Reproduction·Youngsok ChoiAleksandar Rajkovic
Apr 4, 2009·Zoological Science·Yumiko AokiMinoru Tanaka
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Atsushi SuzukiYumiko Saga

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Citations

Nov 3, 2015·Reproductive Toxicology·Karina GutierrezPaulo B D Gonçalves
Feb 15, 2013·Molecular Reproduction and Development·Fangfang Lai, Mary Lou King
Jan 1, 2014·Genesis : the Journal of Genetics and Development·Nathalie Oulhen, Gary M Wessel
Mar 22, 2015·In Vitro Cellular & Developmental Biology. Animal·Dong LiBichun Li
Jun 19, 2012·Cell Stem Cell·Ruth Lehmann
Jun 7, 2014·Frontiers in Genetics·Toshifumi Inada, Shiho Makino
Jul 18, 2016·Developmental Biology·Nathalie Oulhen, Gary M Wessel
Nov 17, 2017·Journal of Cellular Biochemistry·Wenhui ZhangBichun Li
Jun 5, 2019·International Journal of Molecular Sciences·Jian ZhangYa-Qing Chang
Nov 28, 2019·Biomolecules·Tsutomu EndoDirk G de Rooij
Aug 20, 2011·Journal of Cell Science·Annegret BördleinAndreas Winterpacht

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