Function of nucleoid-associated proteins in chromosome structuring and transcriptional regulation

Journal of Molecular Microbiology and Biotechnology
Charles J Dorman

Abstract

Nucleoid-associated proteins typically are abundant, low-molecular-mass polypeptides that bind DNA and alter its shape and its ability to participate in transactions such as transcription. Some can bind RNA and influence the gene expression profile of the cell at a posttranscriptional level. They also have the potential to model and remodel the structure of the nucleoid, contributing to chromosome packaging within the cell. Some nucleoid-associated proteins have been implicated in the facilitation of chromosome evolution through their ability to silence transcription, allowing new genes to be integrated into the nucleoid both physically and in a regulatory sense. The dynamic composition of the population of nucleoid-associated proteins in model bacteria such as Escherichia coli and Salmonella enterica links nucleoid structure and the global regulation of gene expression, enhancing microbial competitive fitness and survival in complex environments.

Citations

Dec 25, 2016·The EMBO Journal·Rodrigo Arias-CartinChristine Jacobs-Wagner
Apr 20, 2016·Proceedings of the National Academy of Sciences of the United States of America·Natalia N VtyurinaElio A Abbondanzieri
Jul 17, 2016·Nucleic Acids Research·Teresa Del Peso Santos, Victoria Shingler
Aug 23, 2020·Biomolecules·Veronika VozárikováĽubomír Tomáška
Jul 1, 2017·Applied Microbiology and Biotechnology·Lucía Feijoo-SiotaTomás G Villa
Sep 14, 2018·Frontiers in Microbiology·Thøger J KroghChristoph Kaleta
May 28, 2019·Frontiers in Cellular and Infection Microbiology·Pavla StojkovaJiri Stulik
Nov 24, 2016·Environmental Microbiology·Simon LeonardSylvie Reverchon
Apr 18, 2018·Frontiers in Microbiology·María-José FerrándizAdela G de la Campa
Mar 3, 2020·Current Opinion in Microbiology·Charles J DormanMark J Buttner
Sep 25, 2017·Biochemical and Biophysical Research Communications·Chinmay AnandValakunja Nagaraja
Jan 9, 2018·Journal of Molecular Biology·Kiyoto KamagataReid C Johnson
Nov 16, 2021·Frontiers in Microbiology·Parul PalRicha Priyadarshini

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