Function of Pro-Resolving Lipid Mediator Resolvin E1 in Type 2 Diabetes

Critical Reviews in Immunology
Corneliu SimaT E Van Dyke

Abstract

Programming of inflammation resolution is governed by a class of specialized pro-resolving lipid mediators (SPMs) that act in concert to modulate epithelial, endothelial, and immune cell function for restoration of homeostasis. The resolution circuits are altered in obesity and associated morbidities, including type 2 diabetes mellitus (T2D), through reduced production and/or action of SPMs, which can be rescued by therapeutic SPM delivery or up-regulation of SPM receptors. Resolvin E1 (RvE1), an eicosapentaenoic acid derivative, has potent pro-resolving and insulin-sensitizing actions mediated by BLT1 and ERV1 receptors in the vasculature and metabolic organs. Nonetheless, the RvE1-mediated increase in protective adipokines such as adiponectin in white adipose tissues, the enhancement of monocyte patrolling function in the vasculature, as well as the macrophage-clearing functions improve metabolic control in obese-prone conditions. RvE1-enhanced resolving function in obesity prevents dysbiosis of the gut microflora and increased gut permeability. These functions suggest that RE1 has therapeutic potential for immunometabolic alterations associated with T2D in patients with reduced inflammation resolving capacity. SPM profiling ...Continue Reading

Citations

Oct 11, 2019·Current Opinion in Nephrology and Hypertension·Ross DoyleEoin Brennan
Mar 13, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Maurizio BruschiGiovanni Candiano
Jun 25, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anandita PalSaame Raza Shaikh
Nov 20, 2018·Journal of Leukocyte Biology·Corneliu SimaMichael Glogauer
Jan 29, 2021·PloS One·Gustavo Ignacio Diaz-RubioRosa-Elena Navarro-Hernández
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