Function of upper esophageal sphincter during swallowing: the grabbing effect

The American Journal of Physiology
P Pouderoux, P J Kahrilas

Abstract

This study investigated deglutitive axial force developed within the pharynx, upper esophageal sphincter (UES), and cervical esophagus. Position and deglutitive excursion of the UES were determined using combined manometry and videofluoroscopy in eight healthy volunteers. Deglutitive clearing force was quantified with a force transducer to which nylon balls of 6- or 8-mm diameter were tethered and positioned within the oropharynx, hypopharynx, UES, and cervical esophagus. Axial force recordings were synchronized with videofluoroscopic imaging. Clearing force was dependent on both sphere diameter (P < 0.05) and location, with greater force exhibited in the hypopharynx and UES compared with the oropharynx and esophagus (P < 0.05). Within the UES, the onset of traction force coincided with passage of the pharyngeal clearing wave but persisted well beyond this. On videofluoroscopy, the persistent force was associated with the aboral motion of the ball caught within the UES. Force abated with gradual slippage of the UES around the ball. The force attributable to the combination of UES contraction and laryngeal descent was named the grabbing effect. The grabbing effect functions to transfer luminal contents distal to the laryngeal in...Continue Reading

Citations

Oct 29, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Lara FerrisTaher Omari
Aug 26, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Francis O EdeaniReza Shaker

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