Function, structure and therapeutic potential of complement C5a receptors

British Journal of Pharmacology
Peter N MonkDavid P Fairlie


Complement fragment (C)5a is a 74 residue pro-inflammatory polypeptide produced during activation of the complement cascade of serum proteins in response to foreign surfaces such as microorganisms and tissue damaged by physical or chemical injury. C5a binds to at least two seven-transmembrane domain receptors, C5aR (C5R1, CD88) and C5L2 (gpr77), expressed ubiquitously on a wide variety of cells but particularly on the surface of immune cells like macrophages, neutrophils and T cells. C5aR is a classical G protein-coupled receptor that signals through G alpha i and G alpha 16, whereas C5L2 does not appear to couple to G proteins and has no known signalling activity. Although C5a was first described as an anaphylatoxin and later as a leukocyte chemoattractant, the widespread expression of C5aR suggested more general functionality. Our understanding of the physiology of C5a has improved significantly in recent years through exploitation of receptor knockout and knocking mice, C5 and C5a antibodies, soluble recombinant C5a and C5a analogues and newly developed receptor antagonists. C5a is now also implicated in non-immunological functions associated with developmental biology, CNS development and neurodegeneration, tissue regenerat...Continue Reading


Jan 1, 1979·Journal of Periodontal Research·H Okada, M S Silverman
Jan 24, 1992·Journal of Medicinal Chemistry·T J LanzaW K Hagmann
Nov 1, 1991·Journal of Leukocyte Biology·J RubinM S Nanes
Feb 14, 1991·Nature·N P Gerard, C Gerard
Nov 1, 1991·European Journal of Immunology·L I KuppJ G Tew
Jul 1, 1991·Journal of Medicinal Chemistry·M KawaiG W Carter
Sep 1, 1990·Journal of Neuroscience Research·J YaoC A Colton
Dec 1, 1970·The Journal of Clinical Investigation·V A Bokisch, H J Müller-Eberhard
Dec 1, 1980·Cellular Immunology·A K El-NaggarR C Williams
Aug 11, 1995·The Journal of Biological Chemistry·E GianniniF Boulay
Sep 13, 1994·Proceedings of the National Academy of Sciences of the United States of America·A M BuhlG L Johnson
Jul 15, 1996·The Journal of Clinical Investigation·M S MulliganP A Ward
Sep 20, 1996·Science·C R BozicN P Gerard

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