PMID: 6165679Jan 1, 1981Paper

Function, target-cell preference and cell-surface characteristics of herpes-simplex virus type-2-induced non-antigen-specific killer cells

Immunobiology
D ArmerdingH Rossiter

Abstract

Wild-type and congenitally athymic nude mice injected with herpes-simplex virus type 2 (HSV 2) responded with a local outburst of non-antigen-specific killer cells masking any virus-specific response. Cytolytic activity could be assayed on mouse-tumor cell lines and on syngeneic or allogeneic non-transformed cells from various sources. Some of the tumor cell lines and proteose-peptone-induced peritoneal exudate cells were lysed more efficiently after infection with either HSV 2, vaccinia or influenza A virus. Preference for virus-infected target cells was already expressed 24 hours after HSV-2 injection. Killing activity was not H-2-restricted, not complement- or immunoglobulin-dependent and did not involve Fc receptors. The cytotoxic cells were non-adherent and could be shown to express Thy1, Quat4, and Quat4 cell-surface antigens. They lacked immunoglobulin and Lyt1: Lyt2,3 determinants. The functional and serological characteristics identify the HSV-2-induced cytolytic cells as natural killer (NK) cells. The potential importance of this cell population for natural resistance will be discussed.

References

Mar 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J C RoderF A Troy
Jan 1, 1979·Immunological Reviews·R Kiessling, H Wigzell
Mar 1, 1979·The Journal of Experimental Medicine·O HallerJ Lindenmann
Sep 19, 1979·The Journal of Experimental Medicine·M ChunM K Hoffmann
Jan 1, 1979·Immunological Reviews·R B HerbermanP Puccetti
Jan 1, 1974·Transplantation Reviews·R V Blanden
Jan 1, 1971·The Journal of Experimental Medicine·J G Stevens, M L Cook
Oct 11, 1974·Nature·B Rager-Zisman, B R Bloom

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