Functional aging and gradual senescence in zebrafish

Annals of the New York Academy of Sciences
Shuji Kishi

Abstract

Zebrafish (Danio rerio) has been recognized as a powerful model for genetic studies in developmental biology. Recently, the zebrafish system also has given insights into several human diseases such as neurodegenerative, hematopoietic, and cardiovascular disease, and cancer. Because aging processes affect these and various other human disorders, it is important to compare zebrafish and mammalian senescence. However, the aging process of zebrafish remains largely unexplored, and little is known about functional aging and senescence in zebrafish. In our initial studies to assess aging phenotypes in zebrafish, we have identified several potential aging biomarkers in an ongoing search for suitable ones on zebrafish aging. In aging zebrafish, we detected senescence-associated beta-galactosidase activity in skin and oxidized protein accumulation in muscle. On the other hand, we did not observe lipofuscin granules (aging pigments), which accumulate in postmitotic cells, in muscle of zebrafish with advancing age. Consistently, there were continuously proliferating myocytes that incorporated BrdU in muscle tissues of the aged fish. Moreover, we demonstrated that zebrafish have constitutively abundant telomerase activity in adult somatic ...Continue Reading

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Citations

May 10, 2012·Molecules and Cells·Sohee Cho, Eun Seong Hwang
Jun 28, 2011·The Journal of Biological Chemistry·Daniela Volonte, Ferruccio Galbiati
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Nov 11, 2021·ELife·Diogo Paramos-de-CarvalhoLeonor Saúde

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