Functional aging in health and heart failure: the COmPLETE Study.

BMC Cardiovascular Disorders
Jonathan WagnerArno Schmidt-Trucksäss

Abstract

Cardiovascular (CV) diseases including heart failure are the leading causes of morbidity, with age being the primary risk factor. The combination of age-related organic functional impairment and reduced physical fitness can drastically impact an individual's healthspan. One's lifespan can potentially be prolonged by the preservation or improvement of physical fitness. However, it remains unclear as to which biomarkers are most suitable for distinguishing between healthy aging and the impaired organ function associated with heart failure. Therefore, a comprehensive assessment of the components of physical fitness and CV function will be performed to identify the most important factors contributing to aging in relation to both health and disease. This cross-sectional investigation will consist of two parts: COmPLETE-Health (C-Health) and COmPLETE-Heart (C-Heart). C-Health will examine the aging trajectories of physical fitness components and CV properties in a healthy population sample aged between 20 and 100 years (n = 490). Separately, C-Heart will assess the same markers in patients at different stages of chronic heart failure (n = 80). The primary outcome to determine the difference between C-Health and C-Heart will be cardio...Continue Reading

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Citations

Apr 1, 2020·Medicine and Science in Sports and Exercise·Jonathan WagnerRaphael Knaier
Aug 23, 2020·Medicine and Science in Sports and Exercise·Jonathan WagnerArno Schmidt-Trucksäss
May 6, 2021·Metabolites·Justin CarrardArno Schmidt-Trucksäss
Jan 21, 2021·Journal of Hypertension·Karsten KönigsteinArno Schmidt-Trucksäss
Nov 16, 2021·BMC Medical Research Methodology·Fabian SchwendingerRaphael Knaier

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Methods Mentioned

BETA
blood drawn

Software Mentioned

GENEActiv
Vesselmap
VSS
GeneActive
COmPLETE

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