Functional allele and genotype frequencies of CYP1A2, CYP2B6 and iNOS among mainland Chinese Tibetan, Mongolian, Uygur and Han populations

Journal of Clinical Pharmacy and Therapeutics
G-Z QiG-L Zhang

Abstract

Cytochrome P450 1A2 (CYP1A2), CYP2B6 and inducible nitric oxide synthase (iNOS) are involved in the metabolism and action of many important therapeutic drugs, and genetic variants have been associated with interethnic differences in response to treatment, including chemotherapy. Eight hundred and forty-two unrelated Chinese healthy subjects (323 Tibetan, 134 Mongolian, 162 Uygur and 223 Han) were recruited for genotyping. Frequencies of CYP1A2 -163C>A, CYP2B6 516G>T and iNOS -954G>C were determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods. The frequency of CYP1A2-163A was higher in Chinese Mongolian (0·698) than in Chinese Tibetan (0·633), Uygur (0·633) and Han populations (0·608, P < 0·05), respectively. The frequency of CYP1A2-163A in the Chinese population (total, 0·636) was intermediate between those reported in Caucasians (0·682, P < 0·05) and Africans (0·549, P < 0·01). The frequency of CYP2B6 516T in Chinese Uygur (0·287) was significantly higher than those in Chinese Tibetan (0·147, P < 0·01) and Mongolian (0·179, P < 0·01), respectively, but was similar to the frequency in Chinese Han (0·226). The frequencies of CYP2B6 516T were in the order of Africans (0·500) > Cauc...Continue Reading

References

Mar 13, 2001·Biochemical and Biophysical Research Communications·N AriyoshiT Kamataki
Sep 21, 2002·European Journal of Clinical Pharmacology·Masahiro HiratsukaMichinao Mizugaki
Nov 26, 2002·British Journal of Clinical Pharmacology·Xing-Mei HanHong-Hao Zhou
Mar 13, 2003·British Journal of Clinical Pharmacology·Samar I HamdyMichinao Mizugaki
Sep 24, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Joo-Youn ChoIn-Jin Jang
Sep 25, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Collet DandaraJulia A Hasler
Oct 16, 2004·Tropical Medicine & International Health : TM & IH·Jakob P CramerUlrich Bienzle
Mar 17, 2005·Drug Metabolism and Pharmacokinetics·Akiko SoyamaJun-ichi Sawada
May 20, 2005·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·A PrawanV Bhudhisawasdi
Jun 1, 2005·Cancer Letters·Karin FransénPeter Söderkvist
Aug 18, 2005·Biochemical and Biophysical Research Communications·Valentina CoiaJürgen F J Kun
Nov 25, 2005·European Journal of Clinical Pharmacology·Carsten SkarkeJörn Lötsch
Mar 21, 2007·European Journal of Clinical Pharmacology·Roza GhotbiLeif Bertilsson
Oct 19, 2007·Nature·UNKNOWN International HapMap ConsortiumJohn Stewart
Dec 17, 2009·American Journal of Human Genetics·Hui LiKenneth K Kidd
Nov 3, 2010·Scandinavian Journal of Immunology·T Qidwai, F Jamal
Jan 1, 2010·Cancer Biomarkers : Section a of Disease Markers·Arvind P SinghDevendra Parmar
Feb 23, 2012·Journal of Toxicology and Environmental Health. Part a·Corie A EllisonJames R Olson
Apr 3, 2012·The Journal of Clinical Endocrinology and Metabolism·Samantha F ButtsTimothy R Rebbeck
Nov 8, 2012·Frontiers in Pharmacology·Guilherme Suarez-KurtzMara Helena Hutz
Jan 21, 2014·Molecular Biology Reports·Fabiana B KohlrauschMara H Hutz
Feb 25, 2014·Molecular Biology Reports·Nazan Yuce-ArtunH Sinan Suzen
Jul 22, 2014·Nature·Emilia Huerta-SánchezRasmus Nielsen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved