Functional analyses of human DNA repair proteins important for aging and genomic stability using yeast genetics.

DNA Repair
Monika Aggarwal, Robert M Brosh

Abstract

Model systems have been extremely useful for studying various theories of aging. Studies of yeast have been particularly helpful to explore the molecular mechanisms and pathways that affect aging at the cellular level in the simple eukaryote. Although genetic analysis has been useful to interrogate the aging process, there has been both interest and debate over how functionally conserved the mechanisms of aging are between yeast and higher eukaryotes, especially mammalian cells. One area of interest has been the importance of genomic stability for age-related processes, and the potential conservation of proteins and pathways between yeast and human. Translational genetics have been employed to examine the functional roles of mammalian proteins using yeast as a pliable model system. In the current review recent advancements made in this area are discussed, highlighting work which shows that the cellular functions of human proteins in DNA repair and maintenance of genomic stability can be elucidated by genetic rescue experiments performed in yeast.

References

Apr 25, 1995·Proceedings of the National Academy of Sciences of the United States of America·J M FlamanJ Benhattar
Dec 1, 1994·The Journal of Cell Biology·B K KennedyL Guarente
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·R K BrachmannJ D Boeke
Dec 1, 1996·Critical Reviews in Biochemistry and Molecular Biology·A Memisoglu, L Samson
May 27, 1997·Proceedings of the National Academy of Sciences of the United States of America·J S HumphreyR D Klausner
Jul 22, 1997·Proceedings of the National Academy of Sciences of the United States of America·J P RadicellaS Boiteux
Aug 29, 1997·Science·D A SinclairL Guarente
Jan 15, 1998·Cell·D A Sinclair, L Guarente
Feb 28, 1998·Science·C H FreudenreichV A Zakian
Feb 14, 1998·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·G M Martin
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·K YamagataH Ikeda
Aug 1, 1998·Nucleic Acids Research·J L Alleva, P W Doetsch
Aug 11, 1998·Nature Genetics·H ShimodairaC Ishioka
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·B J GlassnerL D Samson
Jan 16, 1999·Nucleic Acids Research·A B ClarkT A Kunkel
Jan 5, 2000·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·S J HeoH Ikeda
Aug 1, 2000·Mutation Research·A Memisoglu, L Samson
Nov 23, 2000·Nature·L Guarente, C Kenyon
Jan 11, 2001·Environmental and Molecular Mutagenesis·M Z Hadi, D M Wilson
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·H Cohen, D A Sinclair
Mar 22, 2001·Molecular and Cellular Biology·M C NegrittoA M Bailis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Archaeogenetics

Recent advances in genomic sequencing has led to the discovery of new strains of Archaea and shed light on their evolutionary history. Discover the latest research on Archaeogenetics here.

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.