Functional analysis of cultured neural cells for evaluating cold/cool- and hot/warm-natured Chinese herbs

The American Journal of Chinese Medicine
Yan-Qiu LiuZheng-Tao Wang

Abstract

Recently, modern scientific research has been required to understand pharmacological basis of traditional Chinese medicine (TCM) theory based on the ancient clinical experience, and to investigate the molecular mechanisms of action of Chinese herbs. Here, 20 Chinese herbs, classified into 4 properties (hot, warm, cold and cool) of TCM, were analyzed for their ability to exhibit antioxidant action, to enhance glucose uptake by murine microglia N9 cells, and to influence neurotransmitter norepinephrine (NE) release from rat pheochromocytoma PC12 cells. We found a generally protective effect of both hot/warm-natured and cold/cool-natured herbs against H(2)O(2)-induced N9 cell death, partially by elevating superoxide dismutase (SOD) activity. Glucose uptake was elevated after treatment with some hot/warm-natured herbs. In addition, most herbs with hot/warm nature tended to stimulate NE release, while such stimulatory effect was not observed in the herbs with cold/cool nature. Two cold/cool-natured herbs, Rhizoma coptidis and Radix scutellariae, even significantly suppressed the release. These results suggest that the distinct abilities of Chinese herbs to regulate neural cell functions appear to be correlated with their natures ide...Continue Reading

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Citations

Sep 23, 2014·BioMed Research International·Mingzhi LiaoGuiyou Liu
Feb 15, 2011·Computer Methods and Programs in Biomedicine·Wei LongZhongmei Zou
Oct 4, 2011·Journal of Ethnopharmacology·Miki NakashimaSumio Iwai
Nov 10, 2010·The American Journal of Chinese Medicine·Siming GuanXin Fang
Nov 17, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Changyong LuoXiaohong Gu
Jun 1, 2021·Food Research International·Yifan Zhou, Baojun Xu
Mar 4, 2017·Journal of Chemical Information and Modeling·Xianjun FuAndreas Bender

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