PMID: 18406693May 1, 1995Paper

Functional analysis of mammalian members of the transforming growth factor-beta superfamily

Trends in Endocrinology and Metabolism : TEM
M M Matzuk

Abstract

Analysis of growth factor function has come from studies both in vitro and in vivo. However, the generation of mice deficient in a specific growth factor via gene targeting (for example, "knockout") strategies in embryonic stem (ES) cells will often evaluate the essential roles of the protein in vivo and, in many cases, discover new functions. In this review, studies to date are discussed on the generation and analysis of mice deficient in members of the transforming growth factor (TGF-beta) superfamily. Among the genes targeted via ES cell strategies are the TGF-beta1, Müllerian-inhibiting substance (MIS), inhibin alpha, activin betaA, and activin betaB genes. In addition, the mouse short ear and brachypodism mutants and insertional mutant 413-d have been identified as mutations in the BMP-5, GDF-5, and nodal loci, respectively. These studies have led to critical insights into the functions of these gene products and have further emphasized the importance of members of the TGF-beta superfamily in mammalian development, reproduction, and oncogenesis.

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Citations

Jul 23, 2013·Nature Neuroscience·Veronique E MironCharles Ffrench-Constant
Jan 10, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M IkegameH Kawashima
Jan 25, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Osman V PatelGeorge W Smith
Jun 1, 1997·Baillière's Clinical Obstetrics and Gynaecology·S G Hillier, M Tetsuka
Nov 7, 2006·The Journal of Veterinary Medical Science·Jun-ichi Suto
Jul 4, 2012·Oncoimmunology·Erika VacchelliGuido Kroemer
Oct 29, 1998·Biochemical and Biophysical Research Communications·J L Funk, H Wei
Nov 26, 1998·Molecular and Cellular Neurosciences·S JhaveriM M Matzuk
Nov 10, 2009·Cytokine & Growth Factor Reviews·Christina SieberPetra Knaus
Jun 8, 1999·Human Reproduction·B LorasM Benahmed
Dec 6, 2002·Endocrine Reviews·Hua ChangMartin M Matzuk
Jan 17, 2013·Molecular Endocrinology·Zhilin LiuJoanne S Richards
Feb 12, 2015·Development·Siim Pauklin, Ludovic Vallier
Apr 30, 2021·Circulation Research·Punashi DuttaJoy Lincoln
Nov 4, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Roshan KumariChester W Brown

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