Functional analysis of Mycoplasma arthritidis-derived mitogen interactions with class II molecules.

Infection and Immunity
C BernatchezW Mourad

Abstract

The ability of superantigens (SAGs) to trigger various cellular events via major histocompatibility complex (MHC) class II molecules is largely mediated by their mode of interaction. Having two MHC class II binding sites, staphylococcal enterotoxin A (SEA) is able to dimerize MHC class II molecules on the cell surface and consequently induces cytokine gene expression in human monocytes. In contrast, cross-linking with specific monoclonal antibodies or T-cell receptor is required for staphylococcal enterotoxin B (SEB) and toxic shock syndrome toxin 1 (TSST-1) to induce similar responses. In the present study, we report how Mycoplasma arthritidis-derived mitogen (MAM) may interact with MHC class II molecules to induce cytokine gene expression in human monocytes. The data presented indicate that MAM-induced cytokine gene expression in human monocytes is Zn2+ dependent. The MAM-induced response is completely abolished by pretreatment with SEA mutants that have lost their capacity to bind either the MHC class II alpha or beta chain, with wild-type SEB, or with wild-type TSST-1, suggesting that MAM induces cytokine gene expression most probably by inducing dimerization of class II molecules. In addition, it seems that SEA and MAM int...Continue Reading

References

Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·U BeutnerB T Huber
Feb 1, 1992·The Journal of Experimental Medicine·J W KapplerP Marrack
Feb 1, 1992·The Journal of Experimental Medicine·D R Karp, E O Long
Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J D FraserH Robinson
Aug 1, 1991·Immunology Today·B C Cole, C L Atkin
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·A HermanR P Sekaly
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P SchollT Chatila
Jan 1, 1993·Annual Review of Cell Biology·M T SchererP Marrack
Dec 16, 1994·Science·J ThibodeauR P Sékaly
Jun 15, 1994·Biochemical and Biophysical Research Communications·R al-DaccakW Mourad
Oct 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·L RinkH Kirchner

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Citations

Jan 11, 2000·The Proceedings of the Nutrition Society·L Rink, P Gabriel
Dec 25, 2002·The Journal of Biological Chemistry·Marlene BouillonWalid Mourad
May 10, 2000·The Journal of Nutrition·L Rink, H Kirchner
Dec 5, 1998·Microbiology and Molecular Biology Reviews : MMBR·S RazinY Naot

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