Functional analysis of the putative tumor suppressor PTPRD in neuroblastoma cells

Cancer Investigation
O ClarkA W Stoker

Abstract

The gene encoding PTPδ is mutated or downregulated in human cancers including neuroblastoma. Here, we functionally tested the tumor-suppressive potential of PTPδ in neuroblastoma cell lines by reconstitution of both short and long PTPδ isoforms. We did not observe any significant difference in colony forming ability between cells expressing wild-type or catalytically inactive PTPδ. Although endogenous PTPδ expression was very low in neuroblastoma cells, it was also low in mouse embryo adrenal glands, suggesting that PTPδ may have little developmental function in early adrenal neuroblasts. This study, therefore, questions the significance of PTPδ as a tumor suppressor protein in neuroblastoma.

References

Jan 1, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·L SommerD J Anderson
Feb 28, 2002·Molecular and Cellular Biology·A Radu AricescuAndrew W Stoker
Nov 29, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Pedro J Beltran, John L Bixby
Feb 7, 2003·The Biochemical Journal·Jacquelyn A WoodingsLaura M Machesky
Mar 4, 2003·Nature Reviews. Cancer·Garrett M Brodeur
Mar 5, 2004·International Journal of Cancer. Journal International Du Cancer·Jorge MuñozJavier S Castresana
May 25, 2004·Science·Zhenghe WangVictor E Velculescu
Oct 7, 2004·Developmental Biology·Sonya E Ensslen-Craig, Susann M Brady-Kalnay
Apr 15, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Laurie StepanekJohn L Bixby
Jun 2, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Noriko UetaniMichel L Tremblay
Oct 13, 2006·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Manuel R Gonzalez-Brito, John L Bixby
Dec 1, 2007·Genes, Chromosomes & Cancer·Prakash NairRaymond L Stallings
Feb 27, 2008·The FEBS Journal·Jeroen den HertogFrank-D Böhmer
Dec 17, 2008·Cancer Research·David A SolomonTodd Waldman
May 30, 2009·Proceedings of the National Academy of Sciences of the United States of America·Selvaraju VeeriahTimothy A Chan
Jan 27, 2010·Oncogene·I Janoueix-LeroseyO Delattre
May 11, 2010·Journal of Neuro-oncology·Peter BirnerMarin Guentchev
Jun 19, 2010·The New England Journal of Medicine·John M Maris
Dec 24, 2010·Nature Reviews. Cancer·Sofi G JulienMichel L Tremblay
Nov 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Luc G T MorrisTimothy A Chan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.