Abstract
Left atrial (LA) remodeling and dysfunction reflect chronic exposure to elevated left ventricular (LV) filling pressures. The aim of this longitudinal cohort study was to define the effect of reducing LV filling pressures on reverse remodeling of LA volume (LAV) and function. This retrospective cohort included 195 patients (52% men; mean age, 64 ± 14 years) in sinus rhythm with LA dilatation and sequential echocardiograms (median interval, 1 year; interquartile range, 0.5-2.0 years). One hundred seventy-four patients underwent medical therapy (82 with reduced E/e' ratios), and 21 underwent surgery for valvular heart disease. Biplane LAV (normal value, ≤ 68 mL for men, ≤ 62 mL for women), LA strain (ε) (normal value, >32%) and LV filling pressures (assessed as E/e' ratio; normal value, <13) were measured. Although LAV at baseline and follow-up were 88 ± 27 and 81 ± 24 mL, LA ε and E/e' ratio remained stable at 26 ± 11% and 14 ± 7, respectively. Changes in E/e' ratio were associated with changes in LAV (r = 0.37, P < .001) and LA ε (r = -0.51 P < .001). Although reduced E/e' ratio or improved LA ε at follow-up occurred in about 50% of the patients, only 26% (51 of 195) had normalized LAV. Compared with surgery, successful reducti...Continue Reading
References
Mar 1, 1990·Circulation Research·C P ChengW C Little
Mar 1, 1989·Japanese Journal of Medicine·T KurodaS Hosoda
Aug 15, 1995·Circulation·E J BenjaminD Levy
Oct 7, 1998·The American Journal of Cardiology·A PrioliP Zardini
May 19, 2001·Mayo Clinic Proceedings·T S TsangJ B Seward
Dec 14, 2002·The American Journal of Cardiology·Teresa S M TsangJames B Seward
Aug 11, 2004·Mayo Clinic Proceedings·Marion E BarnesTeresa S M Tsang
Apr 27, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Vincent E HagensUNKNOWN RAte Control versus Electrical Cardioversion for Persistent Atrial Fibrillation Study Group
Jun 7, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Aleksandr RovnerMario J Garcia
Sep 13, 2005·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Carly JenkinsThomas H Marwick
Nov 2, 2005·Circulation·Patricia ReantRaymond Roudaut
Mar 7, 2006·The American Journal of Cardiology·Hsin-Yueh LiangTheodore P Abraham
Jan 5, 2008·Journal of the American College of Cardiology·Grace Casaclang-VerzosaTeresa S M Tsang
Dec 17, 2008·Circulation·Wilfried MullensW H Tang
Feb 4, 2009·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Sherif F NaguehArturo Evangelista
Feb 10, 2009·Cardiovascular Ultrasound·Matteo CameliMaurizio Galderisi
Jul 7, 2009·Heart·Navtej S ChahalRoxy Senior
Oct 8, 2009·Circulation. Cardiovascular Imaging·Christopher P Appleton, Sándor J Kovács
Oct 8, 2009·Circulation. Cardiovascular Imaging·Mustafa KurtSherif F Nagueh
Jul 14, 2011·Heart·Anita C BoydLiza Thomas
Jan 20, 2012·Journal of cardiovascular ultrasound·Jae-Hyeong Park, Thomas H Marwick
Aug 21, 2012·The Canadian Journal of Cardiology·Ae-Young HerHyuck Moon Kwon
Jun 12, 2013·JACC. Cardiovascular Imaging·Masaru ObokataMasahiko Kurabayashi
Nov 10, 2013·The International Journal of Cardiovascular Imaging·Matteo CameliSergio Mondillo
Sep 28, 2014·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Hirohiko MotokiAllan L Klein
Jan 7, 2015·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Roberto M LangJens-Uwe Voigt
Feb 26, 2015·European Heart Journal Cardiovascular Imaging·Roberto M LangJens-Uwe Voigt
Citations
Sep 18, 2016·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Marcelo Haertel MiglioranzaDenisa Muraru
Mar 17, 2017·Journal of the American Heart Association·Oleg F Sharifov, Himanshu Gupta
Oct 13, 2017·Circulation. Cardiovascular Imaging·Erwan DonalFrederic Schnell
Mar 5, 2016·Circulation. Cardiovascular Imaging·Christine L Jellis, Allan L Klein
May 29, 2019·Clinical Physiology and Functional Imaging·Ibadete BytyçiMichael Y Henein
Jul 26, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Manhal IzzyUNKNOWN Cirrhotic Cardiomyopathy Consortium
Apr 17, 2020·Journal of Clinical Medicine·Jan-Thorben SiewekeUdo Bavendiek
Jul 23, 2020·Cardiovascular Ultrasound·Hyukjin ParkJeong Gwan Cho
Aug 1, 2018·The International Journal of Cardiovascular Imaging·Amita SinghRoberto M Lang
May 10, 2019·European Journal of Heart Failure·Luigi P BadanoDenisa Muraru
Oct 3, 2020·Cardiovascular Diabetology·Jeremy M SteeleTarek Alsaied
Nov 28, 2019·Heart Failure Reviews·Giulia Elena MandoliMatteo Cameli
May 5, 2020·The International Journal of Cardiovascular Imaging·Jia-Li FanMing-Han Wang
Jul 23, 2016·Current Cardiology Reports·Ying Wang, Thomas H Marwick
Oct 24, 2020·Pediatric Diabetes·Mayumi IfukuToshiaki Shimizu
Nov 17, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Miki TsujiuchiHiroshi Suzuki
Aug 7, 2021·Echocardiography·Stephen TomlinsonJonathan Chan
Aug 24, 2021·European Heart Journal Cardiovascular Imaging·Alexander C EgbeHeidi M Connolly
Aug 26, 2021·European Heart Journal Cardiovascular Imaging·Elena GalliErwan Donal
Oct 5, 2021·European Heart Journal Cardiovascular Imaging·Diana R FlorescuDenisa Muraru
Oct 27, 2021·Radiology·Yangjie LiYucheng Chen