Oct 11, 2012

Functional and anatomical connectivity abnormalities in cognitive division of anterior cingulate cortex in schizophrenia

PloS One
Hao YanDai Zhang

Abstract

Current pathophysiological theories of schizophrenia highlight the role of altered brain functional and anatomical connectivity. The cognitive division of anterior cingulate cortex (ACC-cd) is a commonly reported abnormal brain region in schizophrenia for its importance in cognitive control process. The aim of this study was to investigate the functional and anatomical connectivity of ACC-cd and its cognitive and clinical manifestation significance in schizophrenia by using the resting-state functional magnetic resonance imaging (fMRI) and the diffusion tensor imaging (DTI). Thirty-three medicated schizophrenics and 30 well-matched health controls were recruited. Region-of-interest (ROI)-based resting-state functional connectivity analysis and Tract-Based Spatial Statistics (TBSS) were performed on 30 patients and 30 controls, and 24 patients and 29 controls, respectively. The Pearson correlation was performed between the imaging measures and the Stroop performance and scores of the Positive and Negative Syndrome Scale (PANSS), respectively. Patients with schizophrenia showed significantly abnormal in the functional connectivity and its hemispheric asymmetry of the ACC-cd with multiple brain areas, e.g., decreased positive conn...Continue Reading

  • References69
  • Citations25

References

Mentioned in this Paper

Premotor Cortex
Right Lentiform Nucleus
Antipsychotic Effect
Structure of Medial Frontal Gyrus
Left Medial Frontal Gyrus
Cortex Bone Disorders
Adrenal Cortex Diseases
Prefrontal Cortex
Stroop Effect
Neostriatum

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