PMID: 11926318Apr 3, 2002Paper

Functional and biochemical characterization of ADAMs and their predicted role in protein ectodomain shedding

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
Carl P Blobel

Abstract

Proteolysis on the cell surface and in the extracellular matrix is essential for normal cellular functions during development and in the adult, but it may also have undesirable consequences by promoting diseases such as cancer, arthritis, and Alzheimer's disease. A particularly interesting function of proteolysis on the cell surface is to release ectodomains of membrane proteins from the plasma membrane. This process, which is referred to as protein ectodomain shedding, affects a variety of proteins with important roles in development and in disease, including cytokines, growth factors, receptors, adhesion proteins and other proteins such as the amyloid precursor protein. In principle, protein ectodomain shedding can dramatically change the properties of a substrate protein. For example, membrane anchored growth factors such as transforming growth factor-alpha (TGF-alpha) are only able to activate their receptor, the epidermal growth factor receptor (EGFR), after they are shed from the plasma membrane. Inhibitor studies have implicated zinc-dependent metalloproteases in protein ectodomain shedding, and in particular a family of metalloproteases termed ADAMs (a disintegrin and metalloprotease). The main focus of my lab is to und...Continue Reading

References

Jan 28, 1999·The Journal of Biological Chemistry·M RoghaniC P Blobel

❮ Previous
Next ❯

Citations

Jan 31, 2004·Biochemical and Biophysical Research Communications·Teresa Villanueva de la TorreJoaquín Arribas
Jun 6, 2003·Cytokine & Growth Factor Reviews·Steven R Wiley, Jeffrey A Winkles
May 29, 2004·Journal of Clinical Pathology·A NoelJ M Foidart
Jan 9, 2004·Reproductive Biology and Endocrinology : RB&E·Daniel D Carson
Feb 8, 2007·Journal of Cell Science·Jia YinFu-Shin X Yu
Aug 2, 2011·Biological Chemistry·Marilena MarziaRiccardo Chiusaroli
Apr 9, 2010·The Journal of Investigative Dermatology·Cornelia MauchPaola Zigrino
Oct 22, 2008·Seminars in Cell & Developmental Biology·Dominique AlfandariHélène Cousin
Mar 18, 2008·The International Journal of Biochemistry & Cell Biology·Marie KveiborgUlla M Wewer
May 20, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C E BrightlingA J Wardlaw
Jul 23, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Juntang LinChristoph Redies
Mar 18, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Juntang LinJiankai Luo
Oct 7, 2003·Oncogene·Thomas Bogenrieder, Meenhard Herlyn
Jan 16, 2004·Gene Therapy·C H EvansS C Ghivizzani
Apr 23, 2004·The EMBO Journal·Olga DolnikViktor Volchkov
Sep 5, 2002·Nature Reviews. Cancer·Christopher Mark Overall, Carlos López-Otín
Mar 17, 2006·European Journal of Immunology·Bruce WalcheckFrank R Deleo
Dec 3, 2009·Journal of Enzyme Inhibition and Medicinal Chemistry·Wen-fang FengYu-zhen Yang
Aug 17, 2004·World Journal of Gastroenterology : WJG·Xiang DingWei-Qun Lu
Feb 5, 2005·The Journal of Biological Chemistry·Tamer RabieBernhard Nieswandt
Sep 15, 2004·The Journal of Biological Chemistry·Christina SundbergUlla M Wewer
Jul 23, 2003·The Journal of Biological Chemistry·Petra MayJoachim Herz
Apr 25, 2003·The Journal of Biological Chemistry·Hassan LemjabbarCarol Basbaum
Dec 16, 2005·The Journal of Biological Chemistry·Katrin DasslerHendrik Fuchs

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Related Papers

Nature Reviews. Molecular Cell Biology
Carl P Blobel
Developmental Dynamics : an Official Publication of the American Association of Anatomists
Amir AsayeshUlf Ahlgren
Gene Expression Patterns : GEP
Samara L LewisDonald F Newgreen
© 2022 Meta ULC. All rights reserved