Functional and Biological Role of Endothelial Precursor Cells in Tumour Progression: A New Potential Therapeutic Target in Haematological Malignancies

Stem Cells International
Antonia RealeRoberto Ria

Abstract

It was believed that vasculogenesis occurred only during embryo life and that postnatal formation of vessels arose from angiogenesis. Recent findings demonstrate the existence of Endothelial Precursor Cells (EPCs), which take partin postnatal vasculogenesis. EPCs are recruited from the bone marrow under the stimulation of growth factors and cytokines and reach the sites of neovascularization in both physiological and pathological conditions such as malignancies where they contribute to the "angiogenic switch" and tumor progression. An implementation of circulating EPCs in the bloodstream of patients with haematological malignancies has been demonstrated. This increase is strictly related to the bone marrow microvessel density and correlated with a poor prognosis. The EPCs characterization is a very complex process and still under investigation. This literature review aims to provide an overview of the functional and biological role of EPCs in haematological malignancies and to investigate their potential as a new cancer therapeutic target.

References

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Citations

Jun 30, 2016·International Journal of Molecular Sciences·Lisa PleyerRichard Greil
Apr 6, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Arjang SalehiAndre Obenaus
Jun 11, 2020·Journal of Clinical Medicine·Roberto RiaAngelo Vacca
May 8, 2020·International Journal of Molecular Sciences·Dorcas Akuba-Muhyia AnnanKyoko Hida
Aug 11, 2020·Frontiers in Cell and Developmental Biology·Christopher Montemagno, Gilles Pagès
Jan 23, 2020·International Journal of Molecular Sciences·Roberto Ria, Angelo Vacca
Nov 7, 2019·Cellular and Molecular Life Sciences : CMLS·Roberta LuganoAnna Dimberg
Feb 28, 2021·Signal Transduction and Targeted Therapy·Bei WangDao Wen Wang
Mar 3, 2020·Translational Oncology·Tiziana AnneseDomenico Ribatti
May 1, 2021·Cancers·Dorina BelottiGiulia Taraboletti

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Methods Mentioned

BETA
biopsy
MDS

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