PMID: 9431843Feb 12, 1998Paper

Functional and genetic studies of the angiotensin II type 1 receptor in pre-eclamptic and normotensive pregnant women

Journal of Hypertension
L MorganN Kalsheker

Abstract

To examine and compare angiotensin II type 1 receptor genotype and its relationship to platelet angiotensin II binding for pre-eclamptic and normotensive pregnant women. In a case-control study, 43 pre-eclamptic women and 83 normotensive women were genotyped at the angiotensin II type 1 receptor gene locus. Platelet angiotensin II binding was measured for a subset of 11 pre-eclamptic and 57 normotensive pregnant women. We genotyped 162 healthy blood donors also, to examine the allelic background and patterns of linkage disequilibrium in the Nottingham population. Patients were recruited during pregnancy using a rigorous definition of pre-eclampsia. DNA was extracted from peripheral venous blood and genotyped at six previously described diallelic polymorphisms in the angiotensin II type 1 receptor gene, using competitive allele-specific oligonucleotide hybridization, and at a dinucleotide repeat polymorphism in the 3' flanking region of the gene. Platelet angiotensin II binding and plasma angiotensin II concentrations were determined for peripheral venous blood. Normotensive pregnant women homozygous for cytosine at nucleotide 573 had significantly higher levels of platelet angiotensin II binding than did heterozygous women and ...Continue Reading

References

May 1, 1977·Clinical Science and Molecular Medicine·F Broughton Pipkin, E M Symonds
Feb 28, 1992·Biochemical and Biophysical Research Communications·H FurutaT Inagami
May 29, 1992·Biochemical and Biophysical Research Communications·N MakitaK F Badr
May 1, 1991·British Journal of Obstetrics and Gynaecology·P N BakerE M Symonds
Sep 1, 1990·British Journal of Obstetrics and Gynaecology·R ArngrimssonG Snaedal
Nov 1, 1973·The Journal of Clinical Investigation·N F GantP C MacDonald
May 1, 1984·The Journal of Clinical Endocrinology and Metabolism·T J MooreG H Williams
Dec 1, 1994·European Heart Journal·A RolfsE Fleck
Jan 1, 1994·Advances in Pharmacology·K K GriendlingR W Alexander
May 1, 1994·Human Molecular Genetics·E DaviesF Soubrier
Aug 1, 1961·American Journal of Obstetrics and Gynecology·R ABDUL-KARIM, S ASSALIN

❮ Previous
Next ❯

Citations

Sep 12, 2000·Current Hypertension Reports·R ShearJ M Moutquin
Sep 3, 2002·Journal of the American College of Cardiology·Lawrence T McGrathGary E McVeigh
Oct 24, 2009·Endocrine Journal·Tomohiro Nakayama, Tatsuo Yamamoto
Jan 11, 2008·Journal of Perinatal Medicine·Sabine MützeWerner Rath
Jul 5, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Linlu ZhaoMichael B Bracken
Mar 31, 2015·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Yingxue LiWeirong Yan
Jul 23, 2005·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Aya MaruyamaTatsuo Yamamoto
Apr 24, 2007·The International Journal of Biochemistry & Cell Biology·Izabela M NitaSabina M Janciauskiene
Nov 23, 2006·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Igor MedicaBorut Peterlin
Dec 19, 2012·Placenta·H D MistryF Broughton Pipkin
Dec 12, 2012·Journal of the Renin-angiotensin-aldosterone System : JRAAS·LuShun ZhangKui Zhang
Mar 4, 2003·Clinical and Experimental Hypertension : CHE·Patricia I PortoCarlos J Pirola

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.