PMID: 1214548Sep 10, 1975Paper

Functional and metabolic changes of the mucosa during the occlusion of the small bowel of the rat (author's transl)

Langenbecks Archiv für Chirurgie
P MerkleD Breitig

Abstract

In this study we investigated the function of the obstructed small bowel of the rat, the behaviour of the mucosal enzymes, the metabolic changes of the small bowel wall and the morphology of the mucosa. We found a decrease of passive transport of 3H-Antipyrine which was equal after 24 and 48 hrs. The active transport of 14C-Glucose was found to be progressively inhibited after occlusion. The metabolic enzymes SDH, G-6-PDH, and GOT remained unchanged, LDH was increased after 48 hrs, which can be explained by enzyme induction. The lactate-pyruvate ratio in the tissue of the obstructed bowel was 3 times as high as in the controls. The brush-border enzymes maltase and especially the alkaline phosphatase are decreased with progressive obstruction, which probably is caused by diffusion into the lumen. By electron-microscopy there are no changes in the brush-border membrane but a swelling of mitochondria which is caused by hypoxia.

References

Jun 19, 1973·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·J KubrováV Mirkovitch
Oct 1, 1965·The British Journal of Surgery·R Shields

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Citations

Aug 1, 1981·European Journal of Clinical Investigation·J B HeneghanB Winistörfer
Jul 22, 1976·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·V MirkovitchF Cobo

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