Functional and metabolic effects of ribose in combination with prazosin, verapamil and metoprolol in rats in vivo.

Cardiovascular Research
S Lortet, H G Zimmer

Abstract

Ribose improves the function of the rat heart in various pathological conditions through its effects on cardiac energy metabolism, while having no direct haemodynamic actions. We therefore studied its functional and metabolic effects in closed chest rats when given in combination with prazosin, verapamil or metoprolol, all of which have direct effects on the circulation. Ribose administration for 24 h at 200 mg.kg-1.h-1 did not affect heart function but increased the available pool of 5-phosphoribosyl-1-pyrophosphate in heart (four fold) and skeletal muscle (1.7-fold), as assessed by the incorporation of 14C-adenine into the adenine nucleotides. The utilisation of adenine for adenine nucleotide synthesis, expressed as the ratio of adenine nucleotide radioactivity to tissue extract radioactivity, was 70% in heart and 20% in skeletal muscle under control conditions, and 97% and 88% after 24 h of ribose administration. Ribose decreased the 14C-adenine incorporation into the adenine nucleotides in kidney, lungs and liver. After 24 h infusion of prazosin (100 micrograms.kg-1.h-1), heart rate and LVdP/dtmax were not changed, but LVSP (-20%), mean aortic pressure (-16%) and peripheral resistance (-40%) were decreased. Cardiac output w...Continue Reading

Citations

Sep 14, 2006·Journal of the American Chemical Society·Shan JiangRobert M Strongin
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·T PageW L Nyhan
Jun 16, 2001·Journal of Applied Physiology·J J Brault, R L Terjung
Aug 1, 1991·The American Journal of Physiology·P C Tullson, R L Terjung

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