PMID: 2418053Nov 1, 1985Paper

Functional and molecular characterization by the CB04 monoclonal antibody of a cell surface structure exerting C3-complement receptor activity

Journal of Clinical Immunology
F MalavasiA P Cappa

Abstract

CB04 monoclonal antibody which reacts with an epitope of a surface molecule expressed on human monocytes has been elicited using peripheral blood lymphocytes as immunizer. The characterization of the monoclonal antibody examined at the phenotypic, molecular, and functional levels indicates that the CB04 antibody defines a structure present on monocytes, tissue macrophages, B cells, polymorphonucleates, and erythrocytes. The molecular weight (220 kD), the tissue distribution in health and disease conditions, and the involvement in relevant biological processes indicate that the CB04 structure is the receptor for the C3b fragment of the complement. The binding of the antibody to the cell surface induces inhibition of the C3bi receptorial function.

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Citations

Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·F MalavasiG Camussi
Sep 1, 1992·Leukemia & Lymphoma·F Lanza, G Castoldi
Feb 1, 1989·Kidney International·D RoccatelloA Amore
Mar 16, 2000·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·M PapottiG Bussolati