Functional and molecular clues reveal precursor-like cells and immature neurones in the turtle spinal cord

The Journal of Physiology
Raúl E RussoOmar Trujillo-Cenóz

Abstract

In lower vertebrates, some cells contacting the central canal (CC) retain the ability to proliferate, leading the reconstruction of the spinal cord after injury. A better understanding about the nature of these cells could contribute to the development of novel strategies for spinal cord repair. Here, by combining light and electron microscopy, immunocytochemistry and patch-clamp recordings, we provide evidence supporting the presence of precursor-like cells and immature neurones contacting the CC of juvenile turtles. A class of cells expressed the ependymal and glial cell marker S100 and displayed morphological and electrophysiological features of radial glia: relatively low input resistance, high resting potential, lack of active membrane properties and extensive dye-coupling. A second class of S100 reactive cells were characterized by a higher input resistance and outward rectification. Finally, some CC-contacting cells expressed HuC/D - a marker of immature neurones - and fired action potentials. The coexistence of cells with functional properties of precursor-like cells and immature neurones suggests that the region surrounding the CC is a site of active neurogenesis. It remains to be demonstrated by lineage analysis wheth...Continue Reading

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Citations

Sep 6, 2007·Cell and Tissue Research·Rebecca A Ihrie, Arturo Alvarez-Buylla
Aug 14, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicolás MarichalRaúl E Russo
Sep 14, 2011·The Journal of Physiology·Cecilia RealiRaúl E Russo
May 10, 2012·The Journal of Physiology·Adeline Orts-Del'immagineJérôme Trouslard
Jan 18, 2014·The Journal of Comparative Neurology·Elham JalalvandSten Grillner
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Mar 10, 2007·The Journal of Comparative Neurology·Omar Trujillo-CenózRaúl E Russo
May 7, 2009·The Journal of Comparative Neurology·María Inés RehermannOmar Trujillo-Cenóz
Mar 1, 2006·The Journal of Comparative Neurology·Myriam AntriRéjean Dubuc
Sep 19, 2009·Nature Reviews. Neuroscience·Elly M Tanaka, Patrizia Ferretti
Dec 10, 2013·Glia·Omar Trujillo-CenózRaúl E Russo
Oct 6, 2017·The Journal of Comparative Neurology·E A B Gilbert, M K Vickaryous
Mar 30, 2018·Frontiers in Neural Circuits·Gabriela FabbianiRaúl E Russo

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