Functional and morphologic evaluation of kidney proximal tubuli and correlation with renal allograft prognosis

Transplant International : Official Journal of the European Society for Organ Transplantation
Ana Cristina Carvalho de MatosA Pacheco-Silva

Abstract

Renal transplant patients with stable graft function and proximal tubular dysfunction (PTD) have an increased risk for chronic allograft nephropathy (CAN). In this study, we investigated the histologic pattern associated with PTD and its correlation with graft outcome. Forty-nine transplant patients with stable graft function were submitted to a biopsy. Simultaneously, urinary retinol-binding protein (uRBP) was measured and creatinine clearance was also determined. Banff's score and semi-quantitative histologic analyses were performed to assess tubulointerstitial alterations. Patients were followed for 24.0 + or - 7.8 months. At biopsy time, mean serum creatinine was 1.43 + or - 0.33 mg/dl. Twelve patients (24.5%) had uRBP > or = 1 mg/l, indicating PTD and 67% of biopsies had some degree of tubulointerstitial injury. At the end of the study period, 18 (36.7%) patients had lost renal function. uRBP levels were not associated with morphologic findings of interstitial fibrosis and tubular atrophy (IF/TA), interstitial fibrosis measured by Sirius red or tubulointerstitial damage. However, in multivariate analysis, the only variable associated with the loss of renal function was uRBP level > or = 1 mg/l, determining a risk of 5.290 ...Continue Reading

References

Jan 1, 1997·Kidney International·D SerónJ Alsina
Sep 12, 1998·Kidney International·K A Nath
Nov 13, 1998·The New England Journal of Medicine·G Remuzzi, T Bertani
Feb 13, 1999·Kidney International·L C RacusenY Yamaguchi
Apr 11, 2000·Current Opinion in Nephrology and Hypertension·G J Becker, T D Hewitson
Mar 16, 2001·American Journal of Physiology. Renal Physiology·E I Christensen, H Birn
Aug 8, 2002·Kidney International·Pierre J VerroustErik Ilsø Christensen
Oct 29, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Pierre J Verroust, Erik I Christensen
May 23, 2003·Journal of the American Society of Nephrology : JASN·Paul C GrimmDavid N Rush
Dec 12, 2003·The New England Journal of Medicine·Brian J NankivellJeremy R Chapman

❮ Previous
Next ❯

Citations

Oct 15, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Luciana de Santis FeltranAlvaro Pacheco-Silva
Feb 19, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H AmerF G Cosio
Sep 8, 2010·Transplant International : Official Journal of the European Society for Organ Transplantation·Trygve SyversveenAudun E Berstad
Jul 3, 2010·Stem Cells·Jakub TolarBruce R Blazar
May 27, 2017·Clinical Journal of the American Society of Nephrology : CJASN·Marco van LondenUNKNOWN NIGRAM Consortium
Mar 17, 2011·Expert Review of Molecular Diagnostics·Valeria R MasDaniel G Maluf
Oct 6, 2017·American Journal of Physiology. Renal Physiology·Marco van LondenMartin H de Borst

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.