Functional and morphological evaluation of canine veins following preservation in different storage media

The Journal of Surgical Research
N CavallariJ D Edwards

Abstract

Injuries of endothelial and smooth muscle cells of autologous vein due to preservation in standard storage media may be responsible for graft failure. The effects of vein preservation with University of Wisconsin solution (UWs) on endothelial and smooth muscle cell function and morphology were compared to the effects of preservation with autologous whole blood (AWB) and normal saline (NS), which are frequently used in cardiovascular surgery. Canine external jugular and common femoral vein segments were preserved in the different solutions at 4 degrees C for 45 min and 24 hr. Rings (4-5 mm in length) from control and preserved veins were evaluated by isometric tension studies at 37 degrees C and by scanning and transmission electron microscopy. Differences between groups were evaluated by Student's t test or Mann-Whitney U test and by analysis of the variance, and considered to be significant at P < 0.05. Sensitivities to norepinephrine (NE) showed that a 45-min vein storage in AWB (5.7 +/- 0.2 mumol/L) but not in NS (5.8 +/- 0.2 mumol/L) or UWs (6.5 +/- 0.2 mumol/L) had a deleterious effect on function of smooth muscle (P < 0.05) when compared to control veins (6.6 +/- 0.2 mumol/L). Maximum contractile responses and sensitiviti...Continue Reading

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Citations

Apr 11, 2003·Fundamental & Clinical Pharmacology·S T L AbrahamseT M van Gulik
Apr 14, 2016·Interactive Cardiovascular and Thoracic Surgery·Bernhard WinklerThierry Carrel
Feb 23, 2010·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·G F MolnárG L Nádasy
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Apr 25, 2020·Minerva cardioangiologica·Sigrid E SandnerMaximilian Y Emmert

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