Functional and morphological relationships between the feline main pancreatic and bile duct sphincters

Gastroenterology
A ThuneJ Svanvik

Abstract

To analyze the relationships between the bile duct and main pancreatic duct sphincters, the resistance to flow through these sphincters was studied simultaneously with perfusion techniques in anesthetized cats. Basal flow resistance was higher in the pancreatic sphincter than in the bile duct sphincter. The pressure in one duct system was not affected by the flow in the other. The muscular activities in the sphincters were usually well coordinated. Distention of the upper biliary tract or the pancreatic duct system reduced the flow resistance in both sphincters. Cholecystokinin-8 (0.01 micrograms), duodenal distention, and sublingual glyceryl trinitrate (0.4 mg) also relaxed both sphincters, whereas secretin in a dose that induced pancreatic secretion had no consistent effect. Morphine increased flow resistance in both systems. These functional studies indicate that the 2 sphincters share smooth muscle fibers at the level where the flow resistances arise, and there are thus no grounds for separate control of the sphincters. There was no evidence of a functionally common sphincter ampulla. The conclusions drawn from the manometric results were supported by morphological findings in this study.

Citations

May 9, 2015·Journal of the American Animal Hospital Association·Minji LeeMhan-Pyo Yang
Apr 1, 1998·Addiction Biology·M V ApteJ S Wilson
Mar 6, 2002·Journal of Feline Medicine and Surgery·R J Washabau
Jun 21, 2002·The Journal of Small Animal Practice·P D MayhewR J Washabau
Nov 7, 2001·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B O Al-JiffryG T Saccone
Sep 8, 2010·Journal of Feline Medicine and Surgery·Robert W Furneaux

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.