PMID: 9438651Jan 23, 1998Paper

Functional and morphometric evaluation of offspring kidney after intrauterine undernutrition

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Sandra Regina R LucasFrida Zaladek Gil

Abstract

Pregnant rats were subjected to 50% food restriction during the first or the second half of pregnancy, or throughout pregnancy. The effects of intrauterine food restriction, on kidney function and morphometry were studied in newborn and adult (3 months) offspring. No differences in glomerular diameter were observed in newborn restricted rats compared with controls. The number of glomeruli was significantly lower both in newborn and 3-month-old restricted rats. However, glomerular diameter was increased in 3-month-old rats, which suggests that hypertrophic stimuli were present. The medulla/cortex ratio increased in adult rats submitted to food restriction during pregnancy, a finding that agrees with the preserved sodium and acid excretion, and the normal osmolar and free water clearance observed in these groups. These results show that the reduction in glomerular number is still present 3 months after birth in the progeny of mothers submitted to severe food restriction during pregnancy, suggesting impairment of glomerulogenesis even after birth. Intra utero undernutrition can be regarded as an experimental model of glomerular hypertrophy.

Citations

May 17, 2011·Histochemistry and Cell Biology·F BonominiR Rezzani
Apr 14, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Anja MühleHolm Schneider
May 25, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Leucio D Vieira-FilhoAna D O Paixão
Mar 11, 2004·Current Hypertension Reports·Michelle M Kett, John F Bertram
Mar 27, 2004·European Journal of Pharmacology·Marijke SandersJo De Mey
Sep 27, 2002·Early Human Development·Jorge Reis Almeida, Carlos Alberto Mandarim-de-Lacerda
Aug 1, 2011·Journal of Developmental Origins of Health and Disease·L M BraddickL R Green
Jan 31, 2006·The Proceedings of the Nutrition Society·Kathryn A BrennanMichael E Symonds
Dec 10, 2003·Applied Immunohistochemistry & Molecular Morphology : AIMM·Serdar FilizHakki Dalcik
May 29, 2009·Clinical and Experimental Pharmacology & Physiology·Leucio D Vieira-FilhoAdalberto Vieyra
May 16, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K A BrennanD M Olson
Sep 8, 2007·Canadian Journal of Physiology and Pharmacology·Amanda C BoyceEugenie R Lumbers
May 21, 2009·Pediatrics and Neonatology·Chung-Ming Chen, Hsiu-Chu Chou
Mar 3, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S ReginaT Machado Coimbra
Mar 3, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·F C Luft
Dec 13, 2006·Life Sciences·Graziela S CeravoloMaria Helena C Carvalho
Jul 11, 2012·International Journal of Nephrology·Maria C P FrancoFrida Zaladek Gil
May 20, 2003·Pharmacology & Toxicology·Saad LahlouGloria Pinto Duarte
Aug 25, 2012·Brain Research·Míriam Carmo Rodrigues-BarbosaDeoclécio Alves Chianca
May 4, 2011·Autonomic Neuroscience : Basic & Clinical·Vanessa Moraes BezerraDeoclécio Alves Chianca
Apr 29, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Karla Roberta Martins PucciRosana Rosa Miranda Corrêa
May 1, 2001·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·F C Luft
May 17, 2008·Mediators of Inflammation·Nicoletta IacovidouAriadne Malamitsi-Puchner
Aug 22, 2007·Mediators of Inflammation·Nicoletta IacovidouAriadne Malamitsi-Puchner
Mar 5, 2005·American Journal of Obstetrics and Gynecology·Jorge R Almeida, Carlos A Mandarim-de-Lacerda
Nov 16, 2010·Neuroscience Letters·Vanessa Moraes BezerraDeoclécio Alves Chianca
Apr 3, 2010·American Journal of Hypertension·Maarten P KoenersJaap A Joles
Aug 31, 2011·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·G N Gomes, F Z Gil
Feb 15, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·F M MonteiroA M Cabral
Dec 11, 2007·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Nicoletta IacovidouAriadne Malamitsi-Puchner
Apr 19, 2006·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Rita RezzaniRossella Bianchi
Jul 20, 2007·Reproductive Sciences·Ariadne Malamitsi-PuchnerDemetrios Gourgiotis
Jul 14, 2006·Kidney & Blood Pressure Research·Michiel SchreuderAns van Wijk
Jul 23, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·P PladysA M Nuyt
Aug 12, 2005·Journal of the American Society of Nephrology : JASN·Michiel F SchreuderHenriette A Delemarre-van de Waal
Jul 1, 2005·Journal of the American Society of Nephrology : JASN·Mandy G Keijzer-VeenUNKNOWN Dutch POPS-19 Collaborative Study Group

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.