Functional and pathological relevance of HERC family proteins: a decade later

Cellular and Molecular Life Sciences : CMLS
Susana Sánchez-TenaJose Luis Rosa

Abstract

The HERC gene family encodes proteins with two characteristic domains in their sequence: the HECT domain and the RCC1-like domain (RLD). In humans, the HERC family comprises six members that can be divided into two groups based on their molecular mass and domain structure. Whereas large HERCs (HERC1 and HERC2) contain one HECT and more than one RLD, small HERCs (HERC3-6) possess single HECT and RLD domains. Accumulating evidence shows the HERC family proteins to be key components of a wide range of cellular functions, including neurodevelopment, DNA damage repair, cell growth and immune response. Considering the significant recent advances made regarding HERC functionality, an updated review summarizing the progress is greatly needed at 10 years since the last HERC review. We provide an integrated view of HERC function and go into detail about its implications for several human diseases such as cancer and neurological disorders.

References

Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·J M HuibregtseP M Howley
Jun 20, 1998·The Journal of Biological Chemistry·S E SchwarzM Scheffner
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·A L LehmanM H Brilliant
May 13, 1999·The Journal of Biological Chemistry·R GrossbergerJ M Peters
Aug 12, 1999·Mammalian Genome : Official Journal of the International Mammalian Genome Society·M WalkowiczL Stubbs
Feb 13, 2001·FEBS Letters·C CruzJ L Rosa
Nov 10, 2001·Annual Review of Genomics and Human Genetics·R D Nicholls, J L Knepper
Mar 26, 2003·FEBS Letters·Francesc R Garcia-GonzaloJose Luis Rosa
Aug 28, 2004·Journal of Cell Science·Renate KroismayrJoachim Lipp
Jun 22, 2005·Cellular and Molecular Life Sciences : CMLS·F R Garcia-Gonzalo, J L Rosa
Jan 13, 2006·The Journal of Biological Chemistry·Anahita DasturJon M Huibregtse
Feb 9, 2006·The Journal of Biological Chemistry·Huira Chong-KoperaKun-Liang Guan
Jul 4, 2006·Proceedings of the National Academy of Sciences of the United States of America·Joyce Jing Yi WongKeh-Chuang Chin
Aug 1, 2006·Biochemical and Biophysical Research Communications·Jocelyn S KasperJames A DeCaprio
Aug 4, 2006·Biochemical and Biophysical Research Communications·Tomoharu TakeuchiHideyoshi Yokosawa
Oct 31, 2007·Developmental Biology·Clara I Rodriguez, Colin L Stewart
Apr 30, 2008·Biochimica Et Biophysica Acta·Ouadah HadjebiJose Luis Rosa
Jun 7, 2008·Cellular and Molecular Life Sciences : CMLS·K HochrainerJ Lipp
May 14, 2009·Nature Reviews. Molecular Cell Biology·Daniela Rotin, Sharad Kumar
Dec 22, 2009·Nature Cell Biology·Simon Bekker-JensenNiels Mailand
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Chen ZhaoRobert M Krug
Feb 12, 2010·Annals of the New York Academy of Sciences·Ksenia A Orlova, Peter B Crino
Feb 24, 2010·BMC Evolutionary Biology·Ignacio Marín
Mar 12, 2010·Journal of Virology·Gijs A VersteegAdolfo García-Sastre
Mar 23, 2010·Proceedings of the National Academy of Sciences of the United States of America·Tae-Hong KangAziz Sancar
Mar 24, 2010·Molecular and Cellular Biology·He-Xin ShiChen Wang
Jul 16, 2010·Cancer Research·Wenwen WuTomohiko Ohta
Oct 15, 2010·Journal of Human Genetics·Désirée White, Montserrat Rabago-Smith
Apr 16, 2011·The Journal of Biological Chemistry·Simone KühnleMartin Scheffner

❮ Previous
Next ❯

Citations

Oct 20, 2017·International Journal of Molecular Sciences·Barbara PergolizziEnrico Bracco
Dec 22, 2017·Journal of Cellular Biochemistry·Danjie ZhuFabo Feng
Oct 19, 2017·Cancer Metastasis Reviews·Dong WangWenyi Wei
Jan 21, 2018·Blood Cancer Journal·Patricia JohanssonJan Dürig
Feb 13, 2019·International Journal of Molecular Sciences·Stella TommasiAhmad Besaratinia
Mar 8, 2018·Scientific Reports·Isabel SaezDavid Vilchez
Oct 31, 2019·Molecular Oncology·Jesús García-CanoJose Luis Rosa
Aug 21, 2019·Cell Death & Disease·Min LiYuehong Yang
Jun 26, 2020·Cancers·Joan Sala-GastonJose Luis Rosa
Apr 18, 2017·Immunity & Ageing : I & a·William GalbavyMario J Rebecchi
Jun 22, 2018·NPJ Parkinson's Disease·Faria ZafarBirgitt Schüle
Apr 20, 2019·Frontiers in Physiology·Janine WeberElena Maspero
Aug 27, 2019·Frontiers in Physiology·Jesús García-CanoJose Luis Rosa
Jun 13, 2017·Pharmacology Research & Perspectives·Yat Yee WongLauren A Trepanier
Jun 3, 2018·Cellular and Molecular Life Sciences : CMLS·Jasper Sluimer, Ben Distel
Jan 20, 2017·Molecular Neurobiology·Eva Mª Pérez-VillegasJosé A Armengol
Jul 6, 2019·Frontiers in Oncology·Taiane SchneiderJose Luis Rosa
Jul 23, 2020·Scientific Reports·Mª Angeles Montes-FernándezJosé A Armengol
Mar 23, 2017·Frontiers in Cellular Neuroscience·Masaaki Sato
Jan 5, 2017·Journal of Cell Science·Barbara PergolizziSalvatore Bozzaro
Jan 20, 2021·Cell Death and Differentiation·Nadia HabelRobert Ballotti
Dec 18, 2020·Frontiers in Neuroanatomy·Eva M Pérez-VillegasJosé A Armengol
Jun 5, 2021·Mutation Research. Reviews in Mutation Research·Andrew W CaliriAhmad Besaratinia

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.