Functional and regulatory interactions between Hox and extradenticle genes

Genes & Development
N Azpiazu, G Morata

Abstract

The homeobox gene extradenticle (exd) acts as a cofactor of Hox function both in Drosophila and vertebrates. It has been shown that the distribution of the Exd protein is developmentally regulated at the post-translational level; in the regions where exd is not functional Exd is present only in the cell cytoplasm, whereas it accumulates in the nuclei of cells requiring exd function. We show that the subcellular localization of Exd is regulated by the BX-C genes and that each BX-C gene can prevent or reduce nuclear translocation of Exd to different extents. In spite of this negative regulation, two BX-C genes, Ultrabithorax and abdominal-A, require exd activity for their maintenance and function. We propose that mutual interactions between Exd and BX-C proteins ensure the correct amounts of interacting molecules. As the Hoxd10 gene has the same properties as Drosophila BX-C genes, we suggest that the control mechanism of subcellular distribution of Exd found in Drosophila probably operates in other organisms as well.

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Citations

Sep 8, 1998·Current Opinion in Genetics & Development·R S Mann, M Affolter
Jul 10, 1999·Genes & Development·H D Ryoo, R S Mann
Oct 19, 2007·Genes & Development·Piu WongMichael L Cleary
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Dec 13, 2005·Nature Reviews. Genetics·Joseph C PearsonWilliam McGinnis
Jun 20, 2007·Experimental Hematology·Sonia CellotGuy Sauvageau
Nov 30, 2007·Developmental Neurobiology·Richa DixitMichael Bate
Oct 19, 2002·Mechanisms of Development·Natalia Azpiazu, Ginés Morata
Oct 19, 2012·Cell Adhesion & Migration·Suraj KachgalNancy J Boudreau
Jan 8, 2000·Developmental Biology·K D Henderson, D J Andrew
Feb 4, 2014·Scientifica·Ernesto Sánchez-Herrero
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May 16, 1998·Nature·G Morata, E Sánchez-Herrero
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Sep 15, 2007·Development·Christopher M Walsh, Sean B Carroll
May 2, 2013·Development·Alicia Estacio-GómezFernando J Díaz-Benjumea

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