Functional and structural brain networks in posterior cortical atrophy: A two-centre multiparametric MRI study

NeuroImage. Clinical
Federica AgostaMassimo Filippi

Abstract

This study identified structural and functional brain connectivity alterations in two independent samples of patients along the posterior cortical atrophy (PCA) disease course. Twenty-one PCA patients and 44 controls were recruited from two expert centres. Microstructural damage of white matter (WM) tracts was assessed using probabilistic tractography; resting state (RS) functional connectivity of brain networks was explored using a model free approach; grey matter (GM) atrophy was investigated using voxel-based morphometry. Compared with controls, common patterns of damage across PCA patients included: GM atrophy in the occipital-temporal-parietal regions; diffusion tensor (DT) MRI alterations of the corpus callosum and superior (SLF) and inferior longitudinal fasciculi (ILF) bilaterally; and decreased functional connectivity of the occipital gyri within the visual network and the precuneus and posterior cingulum within the default mode network (DMN). In PCA patients with longer disease duration and greater disease severity, WM damage extended to the cingulum and RS functional connectivity alterations spread within the frontal, dorsal attentive and salience networks. In PCA, reduced DMN functional connectivity was associated w...Continue Reading

Citations

Feb 13, 2019·Current Neurology and Neuroscience Reports·Jacob J RoelofsMark J Edwards
Nov 7, 2019·Current Opinion in Neurology·Samantha K HoldenVictoria S Pelak
Jul 12, 2019·Frontiers in Neurology·Yi ChenGuoping Peng
Dec 23, 2019·NeuroImage. Clinical·Raffaella MigliaccioMassimo Filippi
Jun 1, 2021·Journal of Alzheimer's Disease : JAD·Oleg YersteinMario F Mendez
May 20, 2021·Brain Communications·Margot Juliëtte OvermanSamrah Ahmed

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Methods Mentioned

BETA
PCA

Software Mentioned

JIM5
FMRIB
FSL FSLv5
SPM12
probtrackx
Bedpostx
ICA
FMRIB Diffusion Toolbox
FSL
FNIRT

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