PMID: 1206535Nov 1, 1975Paper

Functional and structural changes in mammalian sympathetic neurones following interruption of their axons

The Journal of Physiology
D Purves

Abstract

The effects of interrupting the axons of principal neurones in the superior cervical ganglion of adult guinea-pigs were studied by means of intracellular recording, and light and electron microscopy. 1. Within 72 hr of axon interruption, the amplitude of exitatory postsynaptic potentials potentials (e.p.s.p.s) recorded in principal neurons in response to maximal preganglionic stimulation declined. E.p.s.p.s were maximally reduced (by more than 70% on average) 4-7 days following interruption, and failed to bring many cells to threshold. E.p.s.p.s. recorded in nearby neurones whose axons remained intact were unaffected. 2. In ganglia in which axon interruption was achieved by means of nerve crush (thus allowing prompt regeneration), mean e.p.s.p. amplitudes began to increase again after about 1-2 weeks. One month after the initial injury many neurones had e.p.s.p.s of normal amplitude, and by 2 months affected neurones were indistinguishable from control cells. Functional peripheral connexions were re-established during the period of synaptic recovery. 3. The mean number of synapses identified electron microscopically in ganglia in which all the major efferent branches had been crushed decreased by 65-70% in parallel with synapti...Continue Reading

Citations

Jul 1, 1994·Progress in Neurobiology·P A Smith
Jun 1, 1979·Journal of Neurocytology·J M Rosenstein, M W Brightman
Apr 1, 1988·Journal of Neurocytology·M B Graeber, G W Kreutzberg
Jul 1, 1995·Brain Research. Brain Research Reviews·F B WangT L Powley
May 1, 1993·Mechanisms of Ageing and Development·T Cowen
Dec 1, 1990·Neuroscience Research·M Kuno
Dec 1, 1992·Pharmacology & Therapeutics·I A Hendry
Jan 1, 1984·Psychoneuroendocrinology·W A BijlsmaW H Gispen
Jan 1, 1991·The International Journal of Neuroscience·R V Krishnan
Jan 1, 1993·British Journal of Neurosurgery·S SoodG M Taori
Mar 24, 2010·The Journal of Physiology·Bradford BrattonRobin McAllen
May 15, 1997·The Journal of Physiology·E M McLachlanJ Jamieson
Jan 1, 1992·Annals of the New York Academy of Sciences·D WeinreichJ H Leal-Cardoso
Jan 1, 1994·The European Journal of Neuroscience·M V Sánchez-VivesR Gallego
Nov 20, 2008·Journal of Neuropathology and Experimental Neurology·Robert E SchmidtKaren G Green
Jul 24, 2007·Progress in Neurobiology·X NavarroAntoni Valero-Cabré
Apr 16, 2004·Journal of Neurobiology·Kristen L BoeshoreRichard E Zigmond
Feb 12, 2009·Journal of Neurochemistry·Woo-Yang KimPamela J Lein
Mar 15, 2008·Journal of Neuroscience Research·Thomas O MundingerGerald J Taborsky
Aug 1, 2012·Neuropathology and Applied Neurobiology·G ÖztürkN Ayşit

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.