Functional and structural connectivity of the amygdala in obsessive-compulsive disorder

NeuroImage. Clinical
Oana Georgiana RusKathrin Koch

Abstract

The amygdala is known to be involved in anxiety processing, but its role in the psychopathology of obsessive-compulsive disorder (OCD) is still unclear. In this MRI study we investigated potential alterations in structural and functional connectivity of the amygdala in 42 adult patients with OCD and 37 healthy subjects. Psychophysiological interaction analysis was used to explore amygdala functional connectivity during a negative affective task. Probabilistic tractography was then employed to study structural connectivity and integrity of underlying white matter fiber tracts. Compared to controls, OCD patients showed a significantly increased functional connectivity of the left amygdala with mostly parieto-occipital regions during task. No structural connectivity differences could be found between the groups. In addition, only patients showed a significant association between functional and structural connectivity of these regions. Moreover, symptom severity was negatively associated with structural integrity of the underlying white matter tracts. Present results emphasize the relevance of the amygdala for OCD and may reflect that neuronal alterations in structural connectivity could be associated with functional connectivity a...Continue Reading

References

Mar 29, 2001·Nature Neuroscience·E A PhelpsM Davis
Oct 28, 2008·Brain : a Journal of Neurology·Odile A van den HeuvelDick J Veltman

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Citations

Oct 28, 2019·Neuroreport·Alina O TeterevaOlga V Martynova
Apr 17, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Maria Paula MazieroMarcelo Q Hoexter

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Software Mentioned

FMRIB
Presentation®
MATLAB
SPM8
probtrackx2
Diffusion Toolbox – FDT
FDT
FSL ( FMRIB Software Library
probFT
SPM

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