Functional and Structural Integrity of Frontoparietal Connectivity in Traumatic and Anoxic Coma.

Critical Care Medicine
Patrice PeranStein Silva

Abstract

Recovery from coma might critically depend on the structural and functional integrity of frontoparietal networks. We aimed to measure this integrity in traumatic brain injury and anoxo-ischemic (cardiac arrest) coma patients by using an original multimodal MRI protocol. Prospective cohort study. Three Intensive Critical Care Units affiliated to the University in Toulouse (France). We longitudinally recruited 43 coma patients (Glasgow Coma Scale at the admission < 8; 29 cardiac arrest and 14 traumatic brain injury) and 34 age-matched healthy volunteers. Exclusion criteria were disorders of consciousness lasting more than 30 days and focal brain damage within the explored brain regions. Patient assessments were conducted at least 2 days (5 ± 2 d) after complete withdrawal of sedation. All patients were followed up (Coma Recovery Scale-Revised) 3 months after acute brain injury. None. Functional and structural MRI data were recorded, and the analysis was targeted on the posteromedial cortex, the medial prefrontal cortex, and the cingulum. Univariate analyses and machine learning techniques were used to assess diagnostic and predictive values. Coma patients displayed significantly lower medial prefrontal cortex-posteromedial cortex...Continue Reading

References

Jul 13, 1974·Lancet·G Teasdale, B Jennett
Feb 13, 2002·Neurology·Joseph T GiacinoN D Zasler
Oct 31, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T E J BehrensS M Smith
Dec 18, 2004·Archives of Physical Medicine and Rehabilitation·Joseph T GiacinoJohn Whyte
Oct 20, 2007·Lancet Neurology·Jane Qiu
Jul 4, 2008·PLoS Biology·Patric HagmannOlaf Sporns
Jun 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Silvina G HorovitzJeff H Duyn
Dec 4, 2009·Trends in Neurosciences·Nicholas D Schiff
Dec 26, 2009·Brain : a Journal of Neurology·Audrey VanhaudenhuyseMelanie Boly
Apr 28, 2011·Neuron·Stanislas Dehaene, Jean-Pierre Changeux
Oct 5, 2012·Annals of Neurology·Davinia Fernández-EspejoAdrian M Owen
Nov 28, 2012·Proceedings of the National Academy of Sciences of the United States of America·Sophie AchardEdward T Bullmore
Sep 21, 2013·Neurology·Carol Di PerriFrancesco Di Salle
Jan 29, 2014·Nature Reviews. Neurology·Joseph T GiacinoNicholas D Schiff
Jan 15, 2015·Nature Reviews. Neurology·David K Menon, Andrew I R Maas
Mar 13, 2016·Annals of Neurology·Cristina RosazzaUNKNOWN Coma Research Center, Besta Institute
Mar 28, 2016·Lancet Neurology·Andrea O RossettiMauro Oddo
Mar 9, 2017·Critical Care Medicine·Stein SilvaLouis Puybasset
May 16, 2017·Lancet Neurology·Nino StocchettiDavid K Menon
Jun 1, 2017·NeuroImage. Clinical·Briguita MalagurskiStein Silva
Nov 11, 2017·Lancet Neurology·Andrew I R MaasUNKNOWN InTBIR Participants and Investigators
Jun 7, 2018·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Zachary D ThrelkeldBrian L Edlow
Nov 14, 2018·JAMA Neurology·Gentle Sunder ShresthaJ Claude Hemphill
Mar 14, 2019·NeuroImage·Brigitta MalagurskiStein Silva

❮ Previous
Next ❯

Citations

Oct 13, 2020·Current Opinion in Neurology·Samuel B Snider, Brian L Edlow

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT01620957
NCT03482115

Software Mentioned

scikit
learn

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.