Functional and transmural modulation of M cell behavior in canine ventricular wall

American Journal of Physiology. Heart and Circulatory Physiology
Norihiro UedaJiashin Wu

Abstract

Previous studies have demonstrated a discrete population of midmyocardial (M) cells in the ventricular myocardium having excessive action potential duration (APD) prolongation during long activation cycle lengths (CL) and under the influence of APD-prolonging agents. However, M cells have not been found in other studies. Existing explanations for the discrepancies appear inadequate. We hypothesized that instead of being a discrete group, M cell behavior is functional and conditionally expressed. We mapped APDs on the cut-exposed transmural surfaces of arterially perfused ventricular wedges from 26 dogs during Na+ current modification with anemone toxin II (ATX-II). Compared with the endocardium, APDs were not statistically different in the parallel layer having the longest mean APD (APDL) and were significantly shorter in the epicardium in the 26 wedges before ATX-II. ATX-II (> or =5 nmol/l) prolonged APD heterogeneously (midmyocardium > endocardium > epicardium). The differences increased at longer CLs. ATX-II (20.0 nmol/l) shifted the APD(L) layer to 32 +/- 6.2% (6 wedges, CL: 4,000 ms) of the transmural thickness from the (sub)endocardium (8.6 +/- 7.2%, 26 wedges, ATX-II free). We detected the presence of M cell behavior (si...Continue Reading

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Citations

Jun 26, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Charles Antzelevitch
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Sep 21, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Norihiro UedaJiashin Wu
May 2, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Hiroshi MoritaJiashin Wu
Jun 22, 2021·Cardiovascular Research·Corentin ChaumontStéphane N Hatem

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