Functional assessment of alphaEbeta7/E-cadherin interactions in the steady state postnatal thymus

Clinical & Developmental Immunology
Susan E Prockop, Howard T Petrie

Abstract

T cell differentiation in the thymus depends on sequential interactions between lymphoid progenitors and stromal cells in discrete regions of the cortex. Here, we show that despite alphaEbeta7 expression by a subset of the earliest intrathymic precursors (and E-cadherin expression by thymic stroma), interaction of these elements is not required for proper localization of early progenitors into the cortex, or for successful steady state differentiation. These findings indicate that despite in vitro data demonstrating alphaEbeta7 mediated adhesion and proliferation of intrathymic T cell precursor populations, T lymphocyte development can proceed independently of alphaEbeta7/E-cadherin interactions.

Citations

Aug 16, 2011·Cellular and Molecular Life Sciences : CMLS·Ivan Dzhagalov, Hyewon Phee
Sep 25, 2012·Journal of Clinical Immunology·Rebecca H BuckleyMarcella Sarzotti-Kelsoe
Nov 12, 2013·Cell Communication & Adhesion·Tanay BhattColin Jamora
Mar 27, 2015·Journal of Leukocyte Biology·David AlfaroAgustín Zapata
Jul 21, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Daniella Arêas Mendes-da-CruzAgustin G Zapata

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