Functional assessment of sexual maturity in male macaques (Macaca fascicularis)

Regulatory Toxicology and Pharmacology : RTP
Craig M Luetjens, Gerhard F Weinbauer

Abstract

Selection of suitable criteria for assessing sexual maturity in the male long-tailed macaque (Macaca fascicularis) has yielded conflicting results. The present retrospective work investigates whether the sole presence of sperm in the baseline semen sample unequivocally (i.e. for every animal) hallmarks complete testicular maturation. For 956 animals providing the baseline semen sample, neither age, body weight nor testes volume unequivocally predicted the presence of sperm in that sample, and for 322 animals these parameters failed to predict testicular histology. In contrast, the presence of sperm in the baseline semen sample correlated with mature testis histology at study termination in every single animal (n=197/322). Surprisingly, for the 125/322 animals without sperm in the baseline semen sample, spermatogenesis was also mature in 95 animals. Thus, the mere provision of a semen sample without sperm--implying peripheral reproductive tract maturation--was associated with mature spermatogenesis in approx. 75% of animals. Interestingly, testicular maturation occurred approx. 2 years earlier in Mauritian compared to Asian mainland animals. In conclusion, a single semen sample that contains sperm provides unequivocal evidence f...Continue Reading

References

Nov 1, 1990·Archives of Disease in Childhood·F SchaeferK Schärer
Jan 1, 1985·Archives of Andrology·Z Janczewski, L Bablok
Jul 1, 1983·Journal of Steroid Biochemistry·M A RivarolaH E Chemes
Jun 1, 1983·The Journal of Clinical Endocrinology and Metabolism·B B BercuH C Sachs
Feb 1, 1983·International Journal of Andrology·P M KluinD G de Rooij
Feb 1, 1995·American Journal of Physical Anthropology·S H LawlerL L Taylor
Sep 1, 1993·Archives of Disease in Childhood·J L PedersenN E Skakkebaek
Jul 27, 2001·American Journal of Human Biology : the Official Journal of the Human Biology Council·C Y Ji
Sep 25, 2002·International Journal of Andrology·T G CooperE Nieschlag
Feb 10, 2006·Annals of the New York Academy of Sciences·Tony M PlantGary R Marshall
Feb 3, 2007·Nature Reviews. Drug Discovery·Kathryn ChapmanIan Ragan
Jan 26, 2010·Drug Discovery Today·Kathryn L ChapmanIan Ragan
Dec 1, 2008·Toxicologic Pathology·Gerhard F WeinbauerJ Mark Cline
Oct 12, 2010·International Journal of Toxicology·Pauline L Martin, Gerhard F Weinbauer
Oct 13, 2010·Regulatory Toxicology and Pharmacology : RTP·Paul Baldrick

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Citations

Jun 27, 2015·Regulatory Toxicology and Pharmacology : RTP·John C KozloskyMichael J Graziano
Jul 31, 2013·Regulatory Toxicology and Pharmacology : RTP·Paul Baldrick
Jun 24, 2014·Trends in Genetics : TIG·Tanja HausChristian Roos
Jun 22, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Aylwyn Scally
Dec 3, 2013·Toxicologic Pathology·Céline ThuilliezBéatrice Gauthier
Oct 23, 2016·Toxicologic Pathology·Akihisa KangawaMasatoshi Shibata
May 27, 2016·Toxicologic Pathology·Paul W SnyderRoberto E Guzman
Jun 3, 2017·Toxicologic Pathology·Marcia E Pereira BacaresDianne Creasy
Nov 20, 2016·Toxicologic Pathology·Catherine A Picut, Amera K Remick
Dec 1, 2018·American Journal of Primatology·R Robin Baker, Todd K Shackelford
Oct 25, 2017·Birth Defects Research·Catherine A PicutD Stanislaus

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