Functional Association between Regulatory RNAs and the Annexins

International Journal of Molecular Sciences
Katia Monastyrskaya

Abstract

Cells respond to pathophysiological states by activation of stress-induced signalling. Regulatory non-coding microRNAs (miRNAs) often form stable feed-forward loops which ensure prolongation of the signal, contributing to sustained activation. Members of the annexin protein family act as sensors for Ca2+, pH, and lipid second messengers, and regulate various signalling pathways. Recently, annexins were reported to participate in feedback loops, suppressing miRNA synthesis and attenuating stress-induced dysregulation of gene expression. They can directly or indirectly associate with RNAs, and are transferred between the cells in exosomes and shed microvesicles. The ability of annexins to recruit other proteins and miRNAs into exosomes implicates them in control of cell-cell interactions, affecting the adaptive responses and remodelling processes during disease. The studies summarized in this Review point to an emerging role of annexins in influencing the synthesis, localisation, and transfer of regulatory RNAs.

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Citations

May 15, 2018·International Journal of Molecular Sciences·Carles RenteroCarlos Enrich
Aug 23, 2020·Cancers·Stefano Rossetti, Nicoletta Sacchi
Sep 15, 2020·Seminars in Cell & Developmental Biology·Kate DickerAlfredo Castello
Nov 11, 2020·Cell Proliferation·Luyen Tien VuMinh T N Le
Jan 5, 2021·Journal of Extracellular Vesicles·Fabrizio FabbianoVito G D'Agostino
Nov 1, 2020·Drug Discovery Today·Batoul Farran, Ganji Purnachandra Nagaraju

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BETA
antisense oligonucleotides
PCA

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