PMID: 6170068Jul 1, 1981Paper

Functional association of idiotypic and I-J determinants on the antigen receptor of suppressor T cells

Proceedings of the National Academy of Sciences of the United States of America
K OkudaM E Dorf

Abstract

The serological characteristics of the antigen receptor on 4-hydroxy-3-nitrophenylacetyl (NP) specific suppressor T cell hybridomas were analyzed. Three T-cell hybrids could be lysed with anti-idiotype and complement. The reactivity pattern observed from a panel of anti-idiotypic reagents indicated that NPb determinants were detected on all three hybrid lines. NP conjugates with bovine serum albumin or caproic acid specifically inhibited the complement-mediated lysis of these cells by both anti-NPb idiotype and anti-I-J antisera. These hapten conjugates failed to block lysis by anti-Thy 1 or anti-H-2K antisera on the same target cell populations. The data indicate that both I-J and Igh variable region gene products are intimately involved in the recognition of antigen by suppressor T cells. Finally, the suppressor cell hybrids produce soluble factors that mediate antigen-specific suppression. The characteristics of the cells and their factors indicate that the hybrids correspond to the Tsi or first-order suppressor cells in the suppressor cell pathway.

References

Jan 1, 1977·Immunological Reviews·O Mäkelä, K Karjalainen
Feb 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·L L PerryM I Greene
Oct 1, 1979·The Journal of Experimental Medicine·Y Dohi, A Nisonoff
Jun 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·S T JuM E Dorf
Jan 1, 1972·Vox Sanguinis·M E DorfD B Amos
Jan 1, 1981·Scandinavian Journal of Immunology·B Benacerraf, R N Germain

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Citations

Feb 25, 1983·Journal of Immunological Methods·T M Folks, K W Sell
Nov 5, 2002·Immunology Letters·I Athanassakis, S Vassiliadis
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S MiyataniT Tada
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·V K KuchrooM E Dorf
Apr 1, 1987·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·C E SotomayorD T Masih
Feb 1, 1982·The Journal of Experimental Medicine·A F Clark, J D Capra
Aug 1, 1982·The Journal of Experimental Medicine·M MinamiM E Dorf
May 1, 1983·The Journal of Experimental Medicine·M MinamiM E Dorf
Jun 1, 1983·The Journal of Experimental Medicine·I AokiM E Dorf
Jan 1, 1982·Annals of the New York Academy of Sciences·B BenacerrafM E Dorf
Jan 1, 1982·Annals of the New York Academy of Sciences·M J NellesA Nisonoff
Apr 1, 1985·Immunological Reviews·M Taniguchi, T Sumida
Oct 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K OkudaK Hamajima
Jan 10, 2002·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Kenji HamajimaKenji Okuda

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