Functional ATP receptors in rat anterior pituitary cells

The American Journal of Physiology
C VillalobosJavier García-Sancho

Abstract

The effects of ATP and other nucleotides on the cytosolic Ca2+ concentration ([Ca2+]i) of single immunocytochemically typed anterior pituitary (AP) cells have been studied. ATP increased [Ca2+]i in a large percentage (60-88%) of all five AP cell types: lactotropes, somatotropes, corticotropes, gonadotropes, and thyrotropes. Additivity experiments suggest the presence of at least two different receptors, one accepting both ATP and UTP (U receptor), producing Ca2+ release from the intracellular stores, and the other preferring ATP (A receptor), producing Ca2+ (and Mn2+) entry. The characteristics of the U and A receptors were consistent with those of P2Y2 and P2X2, respectively, and their distribution in the different AP cell types was not homogeneous. The presence of other ATP receptors such P2Y1 or P2X2/P2X3 heteropolymers in a small fraction of the cells cannot be excluded. Thus functional ionophoric P2X receptors, which are typical of neural tissue, are also present in the pituitary gland and could contribute to regulation of the gland's function.

References

Jun 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C VillalobosJ García-Sancho
Jul 14, 1989·Biochemical and Biophysical Research Communications·M T AlonsoJ García-Sancho
Dec 1, 1989·Biochemical Society Transactions·J Garcia-SanchoA Sanchez
Jul 15, 1995·The Journal of Physiology·M A Carew, W T Mason
Oct 1, 1994·Trends in Neurosciences·H Zimmermann
Jul 17, 1995·Biochemical and Biophysical Research Communications·G D HousleyA F Ryan
May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·Z P ChenS L Lightman
Feb 1, 1995·Journal of Neuroendocrinology·Z P ChenS L Lightman
Oct 1, 1993·Endocrine Reviews·J W Putney, G S Bird
Dec 1, 1995·The American Journal of Physiology·L NuñezJ García-Sancho
Oct 1, 1995·Pflügers Archiv : European journal of physiology·C Villalobos, J García-Sancho
Apr 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C VillalobosJ Garcia-Sancho
Jan 1, 1996·The European Journal of Neuroscience·L NuñezJ Garcia-Sancho
Mar 1, 1997·Trends in Pharmacological Sciences·B B FredholmM Williams

❮ Previous
Next ❯

Citations

Sep 13, 2006·The European Journal of Neuroscience·Olga A SergeevaHelmut L Haas
Apr 13, 2007·Physiological Reviews·Geoffrey Burnstock
May 20, 2020·Scientific Reports·Leanne GrimesWynand van der Goes van Naters
Oct 21, 2000·Endocrine Reviews·J Schwartz
Aug 22, 2000·British Journal of Pharmacology·H S ChungJ W Lee
Apr 7, 2011·Endocrinology·Shuo LiStanko S Stojilkovic
Sep 13, 2003·The Journal of Biological Chemistry·Mu-Lan HeStanko S Stojilkovic
Dec 17, 2009·American Journal of Physiology. Endocrinology and Metabolism·Hana ZemkovaStanko S Stojilkovic
Nov 23, 2013·Purinergic Signalling·Geoffrey Burnstock
Dec 25, 2015·European Journal of Endocrinology·Cristina L RonchiMartin Fassnacht
May 14, 2011·Purinergic Signalling·Qiang YuGeoffrey Burnstock
Dec 12, 2019·Purinergic Signalling·Wenqi ZhaoZhenghua Xiang
Jul 8, 2017·Molecular and Cellular Endocrinology·Hana Zemková, Stanko S Stojilkovic

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.