Functional attributes of mucosal immunity in cervical intraepithelial neoplasia and effects of HIV infection

Cancer Research
Akiko KobayashiKaren Smith-McCune

Abstract

The role of mucosal immunity in human papillomavirus (HPV)-related cervical diseases is poorly understood. To characterize the local immune microenvironment in cervical intraepithelial neoplasia (CIN) 2/3 and determine the effects of HIV infection, we compared samples from three groups: normal cervix, CIN 2/3 from immunocompetent women (HIV- CIN 2/3), and CIN 2/3 from HIV seropositive women (HIV+ CIN 2/3). CIN 2/3 lesions contained increased numbers of immune cells from both the acquired and innate arms of the immune response in stroma [CD4+ and CD8+ T cells, macrophages, mast cells, B cells, neutrophils, and natural killer (NK) cells] and dysplastic epithelium (CD4+ T cells, macrophages, and NK cells). Immune cells in CIN 2/3 expressed activation markers, as measured by interleukin-2 receptor (IL-2R) and transcription factor T bet. Interferon-gamma production was significantly up-regulated in CIN lesions and was expressed by CD4+ and CD8+ T cells and NK cells, indicating the activation of immune cells. Abundant presence of transforming growth factor-beta+ CD25+ cells in the infiltrates associated with CIN lesions, and of immature CD1a+ dendritic cells expressing IL-10 and transforming growth factor-beta, indicate that CIN is a...Continue Reading

References

Dec 1, 1994·American Journal of Clinical Pathology·N ColemanM A Stanley
Jun 16, 1993·Journal of the National Cancer Institute·M H SchiffmanS Wacholder
Oct 9, 1998·Obstetrics and Gynecology·J MelnikowL P Howell
Jul 10, 1999·Immunological Reviews·I H FrazerM Sharkey
Sep 3, 1999·Clinical and Diagnostic Laboratory Immunology·M ScottA B Moscicki
Feb 24, 2000·Gynecologic Oncology·M C BellP A Crowley-Nowick
Sep 21, 2001·Best Practice & Research. Clinical Obstetrics & Gynaecology·S Man, A Fiander
Oct 31, 2001·Nature Immunology·A HaydayJ Shires
Jan 25, 2002·International Journal of Cancer. Journal International Du Cancer·Sandra L GianniniPhilippe Delvenne
Mar 21, 2002·Nature Reviews. Cancer·Robert W Tindle
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Livio AzzoniLuis J Montaner
Jul 18, 2002·Scandinavian Journal of Immunology·S M AhmedL W Poulter
Nov 22, 2002·The New England Journal of Medicine·Laura A KoutskyUNKNOWN Proof of Principle Study Investigators
Jan 17, 2003·The New England Journal of Medicine·Lin ZhangGeorge Coukos
Feb 7, 2003·The New England Journal of Medicine·Nubia MuñozUNKNOWN International Agency for Research on Cancer Multicenter Cervical Cancer Study Group
Apr 15, 2004·The Journal of the American Board of Family Practice·Gregory TaylorPatricia Langenberg

❮ Previous
Next ❯

Citations

Sep 25, 2008·Clinical & Experimental Metastasis·Janine T Erler, Valerie M Weaver
Aug 30, 2007·AIDS Research and Human Retroviruses·Guillem SireraBonaventura Clotet
Apr 7, 2012·Genetic Testing and Molecular Biomarkers·Andrzej RoszakPaweł P Jagodziński
Sep 22, 2006·Viral Immunology·Juan Manuel Alcocer-GonzálezVicente Madrid-Marina
Nov 25, 2005·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Hermann Brustmann
Jul 18, 2012·Sexually Transmitted Diseases·Mohak MhatreBetsy C Herold
Sep 12, 2008·AIDS·Alessandra PierangeliGuido Antonelli
Apr 12, 2012·Clinical Microbiology Reviews·Margaret A Stanley
Nov 28, 2007·Annual Review of Pathology·Thea D Tlsty, Lisa M Coussens
Feb 22, 2013·Toxicologic Pathology·Carole E HarbisonSusan V Westmoreland
Jan 31, 2014·Science Translational Medicine·Leonel MaldonadoCornelia L Trimble
May 12, 2011·Pathology Research International·Tee U LangLiron Pantanowitz
Jul 12, 2014·Viral Immunology·Mirian Viviane Maciel Barros GuimarãesVictor Hugo Melo
Aug 24, 2012·Critical Reviews in Clinical Laboratory Sciences·Paul K S ChanJong Sup Park
Sep 18, 2008·Cancer Investigation·Victor H Bermudez-MoralesVicente Madrid-Marina
Sep 21, 2011·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Ming-Yih WuHong-Nerng Ho
Dec 20, 2015·American Journal of Reproductive Immunology : AJRI·Niall BuckleyBetsy C Herold
Jun 7, 2011·Annals of Diagnostic Pathology·Janaína Valadares GuimarãesVicente de Paula Antunes Texeira
Jun 14, 2008·Gynecologic Oncology·Margaret Stanley
Jun 14, 2008·Gynecologic Oncology·Warner K Huh, Richard B S Roden
Feb 13, 2007·Current Opinion in Immunology·Graham R Leggatt, Ian H Frazer
May 29, 2009·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Song ChenGuohong Deng
Oct 17, 2007·Clinical and Experimental Immunology·J VisserT Daemen
Nov 28, 2008·BJOG : an International Journal of Obstetrics and Gynaecology·Y L WooM Stanley
Jan 5, 2011·Immunological Reviews·Purnima BhatGraham R Leggatt
Dec 17, 2010·Diagnostic Cytopathology·Liron Pantanowitz, Pam Michelow
Oct 13, 2005·Vaccine·Margaret Stanley
Apr 7, 2012·Annals of Epidemiology·Jill Koshiol, Shih-Wen Lin
Mar 19, 2013·Experimental Cell Research·Andrew J Gunderson, Lisa M Coussens
May 1, 2012·Microbial Pathogenesis·Thiago X CarneiroJuarez A S Quaresma
Jul 13, 2016·American Journal of Reproductive Immunology : AJRI·Uma ShanmugasundaramKaren Smith-McCune

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.