Functional Biomarkers for the Selenium Status in a Human Nutritional Intervention Study

Nutrients
Sandra M MüllerTanja Schwerdtle

Abstract

Soils in Germany are commonly low in selenium; consequently, a sufficient dietary supply is not always ensured. The extent of such provision adequacy is estimated by the optimal effect range of biomarkers, which often reflects the physiological requirement. Preceding epidemiological studies indicate that low selenium serum concentrations could be related to cardiovascular diseases. Inter alia, risk factors for cardiovascular diseases are physical inactivity, overweight, as well as disadvantageous eating habits. In order to assess whether these risk factors can be modulated, a cardio-protective diet comprising fixed menu plans combined with physical exercise was applied in the German MoKaRi (modulation of cardiovascular risk factors) intervention study. We analyzed serum samples of the MoKaRi cohort (51 participants) for total selenium, GPx activity, and selenoprotein P at different timepoints of the study (0, 10, 20, 40 weeks) to explore the suitability of these selenium-associated markers as indicators of selenium status. Overall, the time-dependent fluctuations in serum selenium concentration suggest a successful change in nutritional and lifestyle behavior. Compared to baseline, a pronounced increase in GPx activity and sele...Continue Reading

References

Jul 1, 1989·The Journal of Nutrition·J G YangR F Burk
Oct 1, 1994·The Journal of Nutrition·R F Burk, K E Hill
Jan 1, 1993·Annual Review of Nutrition·R F Burk, K E Hill
Feb 1, 1993·The American Journal of Clinical Nutrition·K Ge, G Yang
Sep 30, 2000·European Journal of Biochemistry·E S Arnér, A Holmgren
Dec 9, 2000·Blood Cells, Molecules & Diseases·L ForsbergR Morgenstern
Feb 24, 2001·Cellular and Molecular Life Sciences : CMLS·J Köhrle
May 12, 2001·The British Journal of Nutrition·G F Combs
Oct 31, 2001·Public Health Nutrition·K M Brown, J R Arthur
May 9, 2002·Molecular and Cellular Biology·Dolph L Hatfield, Vadim N Gladyshev
Mar 4, 2003·The Journal of Nutrition·Michael Hambidge
Apr 9, 2005·The American Journal of Clinical Nutrition·Yiming XiaRaymond F Burk
Apr 15, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Raymond F BurkDaniel W Byrne
May 31, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Catherine MéplanJohn E Hesketh
Jan 5, 2008·The Journal of Biological Chemistry·Gary E OlsonRaymond F Burk
Jun 20, 2008·International Urology and Nephrology·Zorica Arsova-SarafinovskaAleksandar J Dimovski
Apr 7, 2009·Biochimica Et Biophysica Acta·Raymond F Burk, Kristina E Hill
Sep 26, 2009·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·X ForcevilleA Combes
Sep 11, 2010·Free Radical Biology & Medicine·Simone FlorianRegina Brigelius-Flohé
Jun 1, 1980·Biological Trace Element Research·X ChenK Ge
Apr 25, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Raymond F BurkWanqi Zhang
Jul 22, 2014·International Journal of Cancer. Journal International Du Cancer·David J HughesJohn E Hesketh
Oct 5, 2014·International Archives of Occupational and Environmental Health·Th GöenH Drexler
Apr 4, 2015·Nutrients·Gerald F Combs
Apr 30, 2015·Nutrients·Carina BenstoemChristian Stoppe
May 2, 2018·Free Radical Biology & Medicine·Noelia Fradejas-Villar
May 19, 2019·Nutrients·Catalina PicóAndreu Palou
Aug 14, 2019·Nutrients·Lutz SchomburgOlle Melander
Dec 2, 2019·European Journal of Nutrition·Julia BaudryMatthias B Schulze
Dec 7, 2019·European Journal of Heart Failure·Nils BomerPeter van der Meer

❮ Previous
Next ❯

Citations

Oct 4, 2020·Nutrients·Francisco Javier Turrubiates-HernándezJosé Francisco Muñoz-Valle
Feb 12, 2021·Nutrition Reviews·Janaina L S DonadioMarcelo M Rogero
Jun 22, 2021·Frontiers in Nutrition·Rannapaula Lawrynhuk Urbano FerreiraLucia Fatima Campos Pedrosa

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Clinical Trials Mentioned

NCT02637778

Software Mentioned

Prism GraphPad
R blockrand
SELENOP
R Studio

Related Concepts

Related Feeds

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Related Papers

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Fiona A StefanowiczAndrew Duncan
Nutritional Neuroscience
P D Whanger
© 2021 Meta ULC. All rights reserved