Functional brain imaging in survivors of critical illness: A prospective feasibility study and exploration of the association between delirium and brain activation patterns

Journal of Critical Care
James C JacksonVISualizing Icu SurvivOrs Neuroradiological Sequelae (VISIONS) Investigation

Abstract

We undertook this pilot prospective cohort investigation to examine the feasibility of functional magnetic resonance imaging (fMRI) assessments in survivors of critical illness and to analyze potential associations between delirium and brain activation patterns observed during a working memory task (N-back) at hospital discharge and 3-month follow-up. At hospital discharge and 3 months later, fMRI assessed subjects' functional activity during an N-back task. Multiple linear regression was used to examine associations between duration of delirium and brain activity, and elastic net regression was used to assess the relationship between brain activation patterns at 3 months and cognitive outcomes at 12 months. Of 47 patients who underwent fMRI at discharge, 38 (80%) completed the protocol; of 37 who underwent fMRI at 3 months, 34 (91%) completed the protocol. At discharge, the mean (SD) percentage of correct responses on the most challenging version (the N2 version) of the N-back task was 70.4 (23.2; range of 20-100) compared with 76 (23.4; range of 33-100) at 3 months. No association was observed between delirium duration in the hospital and brain region activity in any brain region at discharge or 3 months after adjusting for r...Continue Reading

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Citations

May 19, 2017·Australasian Journal on Ageing·Lucy HaggstromGideon A Caplan
Jun 3, 2017·International Journal of Geriatric Psychiatry·Anita NitchinghamGideon A Caplan
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Jun 10, 2021·BMJ : British Medical Journal·M Elizabeth WilcoxCatherine L Hough

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