PMID: 9447443Jan 1, 1997Paper

Functional brain imaging with single-photon emission computed tomography in the diagnosis of Alzheimer's disease

International Psychogeriatrics
G WaldemarO B Paulson

Abstract

High-resolution single-photon emission computed tomography (SPECT) with brain-retained technetium-99m (99mTc)-labeled tracers may be used for 3-dimensional measurements of regional cerebral blood flow (rCBF). This article summarizes important findings in SPECT studies of Alzheimer's disease (AD). There are three distinct potential applications of SPECT in diagnosing AD: (a) as a diagnostic adjunct in patients with mild cognitive or behavioral symptoms, suggesting a possible dementia disorder; (b) as a diagnostic adjunct for demented patients in whom the history, physical examination, and laboratory studies are in agreement with a diagnosis of probable AD; and (c) for determining the relative contributions of degenerative and vascular pathology to the clinical picture in demented patients with mixed disease. A clinical diagnosis of probable AD is associated with focal perfusion deficits as measured by SPECT. Characteristically, hypoperfusion is observed in the frontal and temporoparietal association areas, whereas other brain regions are relatively spared. The changes are present in the early phases of AD. The topography of rCBF deficits displays a marked heterogeneity among patients and correlates with cognitive profiles. In pa...Continue Reading

Citations

Sep 10, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Torbjörn SundströmKatrine A Riklund
Mar 12, 2008·Annals of Biomedical Engineering·Andreas WindemuthGualberto Ruaño
Dec 13, 2000·Brain Research. Brain Research Reviews·J C de la Torre, G B Stefano
May 20, 2000·Annals of the New York Academy of Sciences·Z SuoM Mullan
May 20, 2000·Annals of the New York Academy of Sciences·J C de la Torre
Sep 3, 2005·American Journal of Alzheimer's Disease and Other Dementias·Barbara E HarrisonBruno J Giordani
Dec 23, 1999·International Journal of Geriatric Psychiatry·C DerouesnéL Lacomblez
Jun 13, 2000·Alzheimer Disease and Associated Disorders·J C de la Torre
Jul 1, 2020·Journal of Alzheimer's Disease : JAD·Wenna DuanWeiying Dai
Sep 22, 2020·Clinical Physiology and Functional Imaging·Anders LassenJens H Henriksen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.