Functional brain reorganization in multiple sclerosis: evidence from fMRI studies

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
P PantanoFrancesca Caramia

Abstract

In patients with multiple sclerosis (MS), the severity of clinical signs is not closely related to indices of structural brain damage provided by conventional magnetic resonance MR. Accordingly, patients with MS may show symptom recovery while progressively accumulating tissue damage. Changes in functional organization of the cerebral cortex have been reported in functional magnetic resonance (fMRI) studies that have compared the activation patterns during motor, visual, and cognitive tasks of patients with MS with those of healthy controls. fMRI studies on MS have provided the results that are difficult to compare and may be discrepant because of differences in the criteria used for patient selection, the activation paradigm, the experimental design, and the MR acquisition parameters. Nevertheless, they do provide a new, interesting tool that sheds light on how the brain changes its functional organization in response to MS. In patients with MS, functional brain reorganization mainly consists of an increase in the extent of activation of the brain areas used by healthy subjects, as well as the recruitment of additional brain areas. These findings have been interpreted as adaptive or compensatory mechanisms that allow normal pe...Continue Reading

References

Sep 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·W I McDonald, D Barnes
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S OgawaD W Tank
May 6, 1972·Lancet·A M HallidayJ Mushin
Mar 10, 1982·The Journal of Comparative Neurology·D D Rasmusson
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·A KarniL G Ungerleider
Dec 24, 1998·Journal of Neurophysiology·J A KleimR J Nudo
Jan 15, 2000·Neurology·H ReddyD L Arnold
Jan 18, 2002·The New England Journal of Medicine·Peter A BrexDavid H Miller
May 3, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A R LangkildeH B W Larsson
Jun 22, 2002·Brain : a Journal of Neurology·Patrizia PantanoGian Luigi Lenzi
May 10, 2003·Stroke; a Journal of Cerebral Circulation·Cinzia Calautti, Jean-Claude Baron
Apr 21, 2004·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Lawrence H SweetRonald A Cohen
Oct 1, 2004·Brain : a Journal of Neurology·Katrin MorgenLeonardo G Cohen
Oct 9, 2004·Multiple Sclerosis : Clinical and Laboratory Research·Richard H C LazeronFrederik Barkhof
Apr 9, 2005·Journal of Clinical and Experimental Neuropsychology·Nancy ChiaravallotiJohn DeLuca
May 20, 2005·Brain : a Journal of Neurology·Patrizia PantanoCarlo Pozzilli

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Citations

Jul 10, 2012·Journal of Neurology·Serafin BeerJürg Kesselring
Mar 20, 2010·Histochemistry and Cell Biology·Gorm Danscher, Agnete Larsen
Jun 7, 2012·Brain Imaging and Behavior·Semyon SlobounovKai Zhang
Jun 26, 2008·Journal of the International Neuropsychological Society : JINS·Frank G Hillary
Mar 11, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Nikos GorgoraptisOlga Ciccarelli
Aug 25, 2012·Multiple Sclerosis : Clinical and Laboratory Research·Robert J FoxKim Zuidwijk
May 15, 2007·Current Opinion in Neurology·Stefanie HoffmannD Yves von Cramon
Oct 16, 2010·Progress in Neurobiology·Ranjan Dutta, Bruce D Trapp
Dec 10, 2008·Neuroimaging Clinics of North America·A L MacKayC Laule
Apr 25, 2008·European Journal of Radiology·Alex Rovira, Adelaida León
Aug 16, 2011·NeuroImage·René A ColoradoPonnada A Narayana
Mar 10, 2007·Journal of the Neurological Sciences·Timothy Vollmer
Nov 29, 2007·Human Brain Mapping·Maria A RoccaMassimo Filippi
Sep 29, 2015·BioMed Research International·Emilia SbardellaPatrizia Pantano
Jul 17, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·U Hofstadt-van OyP Oschmann
Jul 3, 2016·Human Movement Science·Matthew B DownerMichelle Ploughman
Jul 9, 2010·Neurología : publicación oficial de la Sociedad Española de Neurología·A RoviraJ M Prieto
Feb 28, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Emanuele D'AmicoFrancesco Patti
Nov 3, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nicholas A HubbardBart Rypma
Sep 20, 2012·Arquivos de neuro-psiquiatria·Maria José Sá
Jun 17, 2011·Multiple Sclerosis : Clinical and Laboratory Research·Patrizia PantanoCarlo Pozzilli
Jul 31, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Antonio GiorgioNicola De Stefano
Nov 7, 2008·Multiple Sclerosis : Clinical and Laboratory Research·G TedeschiB Alfano
Dec 10, 2009·Multiple Sclerosis : Clinical and Laboratory Research·Carsten UrbanekFriedemann Paul
Nov 23, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Francesco MoriDiego Centonze
Jan 1, 2009·Therapeutic Advances in Neurological Disorders·Ida S HaussleiterGeorg Juckel
Jan 13, 2018·Frontiers in Neuroscience·Mario Stampanoni BassiEnnio Iezzi
Feb 12, 2014·The Cochrane Database of Systematic Reviews·Eija M Rosti-Otajärvi, Päivi I Hämäläinen
Nov 1, 2018·Brain Imaging and Behavior·Laura BonzanoMarco Bove
May 1, 2020·Neurodegenerative Disease Management·Scott RooneyLorna Paul
Feb 1, 2020·Acta Radiologica Open·Mar Jiménez de la PeñaVicente Martínez de Vega
Jan 30, 2019·Neural Plasticity·De Giglio LauraPantano Patrizia

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