Functional calcitonin gene-related peptide type 1 and adrenomedullin receptors in human trigeminal ganglia, brain vessels, and cerebromicrovascular or astroglial cells in culture

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
M J MorenoE Hamel

Abstract

Calcitonin gene-related peptide (CGRP) and adrenomedullin (ADM) are potent dilators of human brain arteries, and they have been implicated in the neurogenic inflammation underlying migraine headache and in the evolution of stroke, respectively. However, little is known about the presynaptic and postsynaptic distribution of their respective receptors in the human cerebrovascular bed and trigeminovascular system. In the current study, the expression of mRNA for ADM and the two cloned human CGRP1 receptors (identified here as A-CGRP1 receptors [Aiyar et al., 1996] and K-CGRP1 receptors) [Kapas and Clark, 1995] were evaluated in human brain vessels and trigeminal ganglia. Further, the ability of CGRP and ADM to activate adenylate cyclase in cerebromicrovascular and astroglial cell cultures was determined, and the receptors involved were characterized pharmacologically. Isolated human pial vessels, intracortical microvessels, and capillaries, as well as cultures of brain endothelial (EC), smooth muscle (SMC), and astroglial (AST) cells, all expressed mRNA for the two cloned CGRP1 receptors; however, message for the K-CGRP1 receptor was barely detectable in microvascular tissues and cells. In contrast, only isolated capillaries and c...Continue Reading

References

Dec 21, 2000·Trends in Pharmacological Sciences·C JuanedaR Quirion
Jan 5, 2002·Peptides·B KisY Ueta
Apr 20, 2002·Journal of Neuroendocrinology·B KisY Ueta
Jan 1, 2006·Drug Discovery Today. Therapeutic Strategies·Blanca Marquez de Prado, Andrew F Russo
Dec 9, 2004·Journal of Neurochemistry·L E Anderson, V S Seybold
Mar 11, 2011·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·M J MorenoM N Bureau
Feb 22, 2013·British Journal of Pharmacology·C S Walker, D L Hay
Apr 26, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Kevin R OliverRaymond G Hill
Nov 24, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M J MorenoE Hamel
Dec 24, 2010·Therapeutic Advances in Neurological Disorders·Sajedeh Eftekhari, Lars Edvinsson
Apr 27, 2018·Cephalalgia : an International Journal of Headache·Liesl N CloseAndrew F Russo
Nov 30, 2018·Expert Opinion on Emerging Drugs·Giorgio LambruPaolo Martelletti
Mar 13, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·B KisY Ueta
Jul 23, 2019·Headache·Jonathan M Borkum
May 24, 2001·Current Opinion in Neurology·A May, P J Goadsby
Jul 3, 2013·International Journal of Inflammation·Kate Marie LewisRobert Vink
Nov 18, 2020·Cephalalgia : an International Journal of Headache·Agustin Melo-CarrilloRami Burstein

Citations

Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·S P SreedharanE J Goetzl
Dec 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Lars EdvinssonR Uddman
Aug 1, 1995·Naunyn-Schmiedeberg's Archives of Pharmacology·D G Linville, E Hamel
Apr 28, 1995·European Journal of Pharmacology·J KatoT Eto
Sep 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R R WhitesellJ M May
Sep 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M K BaskayaK Sugita
Jun 30, 1994·Biochemical and Biophysical Research Communications·S SugoH Matsuo
Mar 21, 1994·FEBS Letters·K KitamuraT Eto
Apr 15, 1994·Biochemical and Biophysical Research Communications·Y IshizakaT Eto
Oct 15, 1993·Biochemical and Biophysical Research Communications·C NukiA Wada
Dec 5, 1995·Proceedings of the National Academy of Sciences of the United States of America·X WangG Z Feuerstein
Dec 26, 1995·Biochemical and Biophysical Research Communications·S Kapas, A J Clark
May 10, 1996·The Journal of Biological Chemistry·N AiyarY Li
May 1, 1997·Stroke; a Journal of Cerebral Circulation·M ZoliL F Agnati
May 1, 1997·Stroke; a Journal of Cerebral Circulation·N J AlkayedD R Harder
Jul 9, 1997·European Journal of Pharmacology·Y MoriH Hidaka
Feb 23, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R AbounaderE Hamel
Nov 24, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M J MorenoE Hamel

Related Concepts

CALCA gene
Calcitonin gene-related peptide (8-37)
Calcitonin Gene-Related Peptide
CALCA wt Allele
Adrenomedullin
Cerebrovascular System
Blood Vessel
Antagonist Muscle Action
Astrocytes
Cell Culture Techniques

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.