Functional capacity of the liver after two-thirds partial hepatectomy in the rat

Surgery
M Hashimoto, K Sanjo

Abstract

Liver cell proliferation after partial hepatectomy in rats has been thoroughly investigated. Although DNA synthesis and morphologic restoration have been studied in this rat model, the functional capacity of the remnant liver during regeneration has not been elucidated. We measured the indocyanine green disappearance rate (ICG-k) and serum aminopyrine (CLamp) in rats at various intervals after two-thirds hepatectomy. Morphologic restoration of the liver after hepatectomy was evaluated on the basis of remnant liver weight, proliferating cell nuclear antigen labeling index, and the DNA content of the regenerating liver. Serial changes in ICG-k and CLamp after two-thirds hepatectomy were compared with the degree of morphologic restoration. ICG-k and CLamp were reduced by one third in rats after two-thirds hepatectomy. Although the rate of restoration of remnant liver weight was steady after hepatectomy, ICG-k and CLamp were lowest about 36 hours after hepatectomy. The restoration of ICG-k was comparable to that of liver weight, but the restoration of CLamp was delayed. Functional liver capacity was minimal during parenchymal cell mitosis in the regenerating liver. Functional restoration after two-thirds hepatectomy was delayed in ...Continue Reading

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Citations

Jul 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ian R CorbinGerald Y Minuk
Dec 11, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Claus U NiemannC Spencer Yost
Jun 3, 2006·Digestive Surgery·Takashi KobayashiMasatoshi Makuuchi
Jul 9, 2011·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Stefano Di DomenicoUmberto Valente
Jul 6, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J R GarbowM W Flye
May 13, 2015·The Journal of Surgical Research·András FülöpAttila Szijártó
Feb 13, 2001·The Journal of Surgical Research·Y IshiiK Ishikawa
Jul 18, 2000·The Journal of Surgical Research·M Hashimoto, G Watanabe
Aug 8, 2009·International Journal of Experimental Pathology·Lorenzo PolimenoAntonio Francavilla
Nov 16, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Chengrong LuFuchu He
Feb 5, 2009·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Attila SzijártóPéter Kupcsulik

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