Functional capacity of the thyroid autograft: an experimental study

The Journal of Surgical Research
B PapaziogasT Papaziogas

Abstract

The aim of this study was to investigate the functional capacity of thyroid autografts after total thyroidectomy in a rabbit model. Thirty-eight rabbits underwent total thyroidetomy. One of the two thyroid lobes was cut into 1-mm pieces and was introduced intramuscularly into the right quadriceps muscle (group A, n = 10), the right rectus abdominalis muscle (group B, n = 10), and the right sacrodorsalis muscle (group C, n = 10). Another group of 8 rabbits underwent total thyroidectomy without autologous implantation and served as the control group (group D). The animals were observed for 8 weeks with weekly measurements of thyroid hormones. At the end of the 8th week, a scintigram was performed. The autografts were removed 2 days later. The thyroid hormone levels showed a gradual decrease until the 2nd-5th week after implantation, followed by a gradual increase and establishment of euthyroid levels between the 5th and 8th weeks. Respectively, an increase of thyreotropin hormone was noted with maximal values in the 4th week, followed by a gradual decrease until the end of the 8th week. The scintigram at the end of the 8th week revealed the presence of functional thyroid tissue in all cases. Functional thyroid follicles were foun...Continue Reading

Associated Clinical Trials

Dec 28, 2020·Mohamed Ahmed Hassan Aly

References

Mar 1, 1988·The British Journal of Surgery·A Y Al-SamarraiA Al-Jobori
Jan 1, 1993·Acta Oto-laryngologica. Supplementum·H IwaiT Kumazawa
Aug 1, 1996·International Journal of Andrology·E J Barten, D W Newling
Nov 27, 1998·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·B M NabishahA Zanariyah
Jun 12, 1999·American Journal of Surgery·J M RabkinD E Sutherland

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Citations

Jul 9, 2011·Head & Neck·Murat KaramanArzu Tatlıpınar
Mar 19, 2014·Head & Neck·Imdat YüceErcihan Güney
May 24, 2017·Clinical and Experimental Otorhinolaryngology·Mahmoud Sakr, Ahmed Mahmoud
Jan 18, 2013·Surgery Today·Enrico ErdasGiampaolo Farina
Oct 28, 2017·Head & Neck·Mahmoud SakrIbrahim Fathi
Jun 4, 2021·Frontiers in Endocrinology·Marcel VasconcellosAlberto Schanaider

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