Functional central polypurine tract provides downstream protection of the human immunodeficiency virus type 1 genome from editing by APOBEC3G and APOBEC3B

Journal of Virology
Sebastien WurtzerFrançois Clavel

Abstract

Lentiviruses utilize two polypurine tracts for initiation of plus-strand viral DNA synthesis. We have examined to what extent human immunodeficiency virus type 1 plus-strand initiation at the central polypurine tract (cPPT) could protect the viral genome from DNA editing by APOBEC3G and APOBEC3B. The presence of a functional cPPT, but not of a mutated cPPT, extensively reduced editing by both APOBEC3G and APOBEC3B of sequences downstream, but not upstream, of the cPPT, with significant protection observed as far as 400 bp downstream. Thus, in addition to other potential functions, the cPPT could help protect lentiviruses from editing by cytidine deaminases of the APOBEC family.

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Citations

Sep 12, 2006·Nucleic Acids Research·Rodolphe SuspèneSimon Wain-Hobson
Sep 17, 2010·Journal of Virology·Chunling HuEric M Poeschla
Sep 29, 2006·Journal of Virology·David J GarfinkelStephen H Hughes
Jun 26, 2008·Retrovirology·Ritu Goila-Gaur, Klaus Strebel
Feb 27, 2010·PloS One·Christophe Fuerer, Roel Nusse
Nov 4, 2011·Viruses·Stéphanie Durand, Andrea Cimarelli
Feb 12, 2008·Virus Research·Renato S Aguiar, B Matija Peterlin
Sep 12, 2006·Biochemical and Biophysical Research Communications·Jan De Rijck, Zeger Debyser
Dec 17, 2010·RNA Biology·Judith G LevinKarin Musier-Forsyth
May 18, 2016·PLoS Pathogens·Krista A Delviks-FrankenberryVinay K Pathak
Dec 4, 2020·Microorganisms·Wendy Kaichun XuJaquelin P Dudley
Jun 25, 2015·Microbiology Spectrum·Stephen H Hughes

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