PMID: 2121273Oct 5, 1990Paper

Functional changes in cation-preferring amino acid transport during development of preimplantation mouse conceptuses

Biochimica Et Biophysica Acta
L J Van Winkle, A L Campione

Abstract

In a previous study, a Na(+)-independent, cation-preferring amino acid transport system was detected in preimplantation mouse blastocysts. The system resisted Na(+)-dependent inhibition by homoserine and so resembled the lysosomal system c more than it resembled the plasmalemmal system y+. We now report the presence of a cation-preferring system in unfertilized and fertilized eggs and cleavage-state conceptuses which also resists Na(+)-dependent inhibition by homoserine. The systems in 1-cell conceptuses and blastocysts are, however, insensitive to changes in pH in the interval of 6.0 to 8.0 and, thus, different from the pH-sensitive system c. Moreover, the relative strengths of the interactions of a variety of basic amino acids with the systems in conceptuses do not correspond well with the relative strengths of their interactions with either system c or system y+. Similarly, the system in 1-cell conceptuses can be distinguished from the system in blastocysts because L-arginine interacts about equally well with each of these systems, whereas the system in 1-cell conceptuses is inhibited more strongly than the system in blastocysts by most other basic amino acids. In addition, inhibition of the system in 1-cell conceptuses by s...Continue Reading

References

Jun 22, 1988·Biochimica Et Biophysica Acta·L J Van WinkleJ M Gorman
Jan 1, 1989·Methods in Enzymology·H N Christensen
Feb 24, 1988·Biochimica Et Biophysica Acta·L J Van Winkle
Aug 13, 1987·Biochimica Et Biophysica Acta·L J Van Winkle, A L Campione
Jan 1, 1985·The Journal of Membrane Biology·H N Christensen
Jul 27, 1970·Biochemical and Biophysical Research Communications·E L Thomas, H N Christensen
Aug 1, 1980·In Vitro·A Spindle
Sep 1, 1957·The Journal of Endocrinology·R E FOWLER, R G EDWARDS

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Citations

Nov 1, 1990·Developmental Biology·L J Van WinkleR L Garton
Jul 1, 1991·Developmental Biology·L J Van Winkle, A L Campione
Nov 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Candace L SteevesJay M Baltz
Jul 17, 2009·Biology of Reproduction·Amélie M D PellandJay M Baltz
Feb 17, 2007·The Journal of Physiology·R Daniel Peluffo
Sep 23, 2014·Molecular Reproduction and Development·Priscila Di Paula Bessa SantanaMoysés dos Santos Miranda
Mar 1, 1993·Molecular Reproduction and Development·R S PratherL J Van Winkle
Jan 3, 2001·Biology of Reproduction·L J Van Winkle
Sep 1, 1993·Molecular Reproduction and Development·R S PratherL J Van Winkle
Dec 26, 2001·Current Opinion in Nephrology and Hypertension·Ellen I Closs
Aug 1, 1991·The American Journal of Physiology·T C FureszC H Smith
Oct 13, 2000·American Journal of Physiology. Cell Physiology·H NawrathE I Closs
Mar 1, 1995·The American Journal of Physiology·T C FureszC H Smith
Oct 28, 1998·Physiological Reviews·M PalacínA Zorzano
Oct 7, 2004·The Journal of Nutrition·Ellen I ClossAlexander Rotmann
Sep 30, 1991·Biochimica Et Biophysica Acta·L J Van WinkleA L Campione

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